INT246835

Context Info Confidence 0.06 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 0.03

cytoplasm (Iars, Ins1) extracellular space (Ins1) extracellular region (Ins1) nucleus (Iars) carbohydrate metabolic process (Ins1) translation (Iars)

Anatomy Link Frequency skeletal muscle 1 Iars (Mus musculus) Ins1 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 7 54.80 cytokine 2 5.00 ketamine 2 5.00 anesthesia 1 5.00 Kinase C 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Insulin Resistance 24 100.00 Diabetes Mellitus 7 92.80 Targeted Disruption 8 75.00 Impaired Glucose Tolerance 9 55.44 Hyperinsulinism 2 53.28 Obesity 8 5.00 Body Weight 4 5.00 Rheumatoid Arthritis 3 5.00 Necrosis 1 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, we examine the role of serine phosphorylation of insulin receptor substrate (IRS)-1 in mediating fat-induced insulin resistance in skeletal muscle in vivo.

IRS Spec (examine) Positive_regulation (induced) of insulin in skeletal muscle associated with insulin resistance

1) Confidence 0.06 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551673 Disease Relevance 0.86 Pain Relevance 0.03

General Comments

This test has worked.