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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.16
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Myd88) signal transduction (Myd88) plasma membrane (Myd88)
intracellular (Myd88) protein complex (Myd88) cytoplasm (Myd88)
Anatomy Link Frequency
outflow 1
granulocyte 1
medial 1
plaque 1
Myd88 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 190 98.88 Very High Very High Very High
Inflammation 260 96.60 Very High Very High Very High
rheumatoid arthritis 140 89.92 High High
Inflammatory response 65 80.56 Quite High
chemokine 54 80.00 Quite High
ischemia 46 76.44 Quite High
Mechanotransduction 12 68.48 Quite High
fibrosis 3 66.72 Quite High
cINOD 5 60.20 Quite High
metalloproteinase 11 51.04 Quite High
Disease Link Frequency Relevance Heat
Wound Healing 12 98.76 Very High Very High Very High
Systemic Lupus Erythematosus 124 98.32 Very High Very High Very High
Injury 345 97.56 Very High Very High Very High
Atherosclerosis 11 97.48 Very High Very High Very High
INFLAMMATION 328 96.60 Very High Very High Very High
Atherosclerotic Plaque 2 96.36 Very High Very High Very High
Apoptosis 98 92.44 High High
Rheumatoid Arthritis 140 89.92 High High
Diabetes Mellitus 76 88.12 High High
Death 26 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, complete loss of Myd88 function, however, results in impaired wound healing and poor neovascularization [53].
Negative_regulation (loss) of Myd88 associated with wound healing
1) Confidence 0.38 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.88 Pain Relevance 0.13
The histologic measurements reported here point to a loss of approximately 40% more islet volume in Myd88?
Negative_regulation (loss) of Myd88
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666970 Disease Relevance 0.06 Pain Relevance 0
MyD88 or TRIF deficiency does not influence renal function and granulocyte influx after I/R induction
Negative_regulation (deficiency) of MyD88 in granulocyte
3) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 1.07 Pain Relevance 0
Despite these methodologic limitations, the absence of superoxide detection in the face of detectable DHE after systemic tempol treatment in WT mice or after outflow reduction in MyD88?
Negative_regulation (reduction) of MyD88 in outflow
4) Confidence 0.36 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.22 Pain Relevance 0.08
The contrasting phenotype of increased medial thickness and medial expansion after decreased blood flow in MyD88?
Negative_regulation (decreased) of MyD88 in medial
5) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2605224 Disease Relevance 0.57 Pain Relevance 0.11
SARM has been shown to interact with TRIF and expression of SARM in HEK293 cells led to the inhibition of TRIF-dependent, but not MyD88-dependent, NF-?
Negative_regulation (inhibition) of MyD88-dependent
6) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.30 Pain Relevance 0.15
Shigeoka et al. observed similar results showing that TLR2 deficiency provided more protection than a deficiency in MyD88 or TRIF individually or a combination of those two adapter molecules [27].
Negative_regulation (deficiency) of MyD88
7) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 0.32 Pain Relevance 0
Two independent groups have shown that inhibiting MyD88 impairs the phosphorylation/activation of downstream kinases [86] and NF?
Negative_regulation (inhibiting) of MyD88
8) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.58 Pain Relevance 0.07
This inhibitor showed similar inhibition of MyD88 signaling indicated by impaired NF?
Negative_regulation (inhibition) of MyD88
9) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.38 Pain Relevance 0.03
Notably, treatment with rhBCL2A1 protein did not protect mice deficient in toll-like receptor-2 (TLR2) or the adaptor protein, myeloid differentiation factor-88 (MyD88).


Negative_regulation (deficient) of myeloid differentiation factor-88
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816997 Disease Relevance 0.72 Pain Relevance 0.16
For example, members of the TAM receptor family inhibit both MyD88 and TRIF pathways by induction of suppressor of cytokine signalling (SOCS)-1 and -3 [83-85].
Negative_regulation (inhibit) of MyD88 associated with cytokine
11) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.13 Pain Relevance 0.12
An apoE (apolipoprotien E)-deficient mouse model has reported that a loss of TLR4 and its adaptor molecule MyD88 (myeloid differentiation factor 88) decreased the severity of atherosclerosis and altered atherosclerotic plaque formation [22].
Negative_regulation (loss) of MyD88 in plaque associated with atherosclerotic plaque and atherosclerosis
12) Confidence 0.20 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.82 Pain Relevance 0.16
For example, MyD88 deficiency impairs both uptake of B. burgdorferi by mouse M?
Negative_regulation (deficiency) of MyD88
13) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.11 Pain Relevance 0.29

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