INT247285

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS) signal transduction (HRAS) Golgi apparatus (HRAS)
plasma membrane (HRAS) nucleus (HRAS) GTPase activity (HRAS)
Anatomy Link Frequency
synovium 6
GLC1N (Homo sapiens)
HRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 56 97.08 Very High Very High Very High
Pain 32 94.68 High High
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 72 97.12 Very High Very High Very High
Pain 32 94.68 High High
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Cancer 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the results of our experiments suggest that GlcN-HCl increases the production of HA in synovium.
GlcN-HCl Positive_regulation (increases) of Gene_expression (production) of HA in synovium
1) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.10 Pain Relevance 0.05
We therefore hypothesized that addition of GlcN might increase HA production by synovium tissue.


GlcN Spec (might) Positive_regulation (increase) of Gene_expression (production) of HA in synovium
2) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2553787 Disease Relevance 0.54 Pain Relevance 0.28
Our data suggest that exogenous GlcN can increase HA production by synovium tissue and is more effective at lower concentrations than Gluc.
GlcN Positive_regulation (increase) of Gene_expression (production) of HA in synovium
3) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2553787 Disease Relevance 0.25 Pain Relevance 0.08
0.5 mM and 5 mM GlcN-HCl significantly increased HA production compared to control (approximately 2 – 4-fold), whereas GlcN-Ac had no significant effect.
GlcN-HCl Positive_regulation (increased) of Gene_expression (production) of HA
4) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2553787 Disease Relevance 0.42 Pain Relevance 0.20

General Comments

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