INT247803

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.03
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh2) plasma membrane (Cdh2) protein complex (Cdh2)
Anatomy Link Frequency
CAR 1
kidney 1
Cdh2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 3 82.32 Quite High
addiction 1 43.36 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cyst 32 99.84 Very High Very High Very High
Polycystic Kidney Disease 62 99.82 Very High Very High Very High
Targeted Disruption 80 99.38 Very High Very High Very High
Arrhythmia Under Development 19 98.90 Very High Very High Very High
Adhesions 20 87.12 High High
Disease 37 84.88 Quite High
Fibrosis 2 82.32 Quite High
Congenital Anomalies 7 78.48 Quite High
Heart Rate Under Development 5 72.12 Quite High
Coronary Artery Disease 2 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the severe AV block in the absence of atrial or ventricular arrhythmia mimicked in the Cx45 KO, we hypothesized that CAR (as described for N-cadherin; reference 6) affects electrical conduction indirectly through gap junctions.
Positive_regulation (described) of N-cadherin in CAR associated with targeted disruption and arrhythmia under development
1) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 1.03 Pain Relevance 0.04
In the ADPKD kidney, N-cadherin is markedly increased in cysts of distal origin [68].
Positive_regulation (increased) of N-cadherin in kidney associated with polycystic kidney disease and cyst
2) Confidence 0.04 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.00 Pain Relevance 0

General Comments

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