INT247819

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cxadr, Rasa1) plasma membrane (Cxadr, Rasa1) mitochondrion organization (Cxadr)
embryo development (Rasa1) protein complex (Cxadr) extracellular space (Cxadr)
Anatomy Link Frequency
CAR 2
Cxadr (Mus musculus)
Rasa1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 1 82.64 Quite High
addiction 1 49.52 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 75 99.54 Very High Very High Very High
Arrhythmia Under Development 19 99.06 Very High Very High Very High
Disease 7 85.20 High High
Fibrosis 1 82.64 Quite High
Heart Rate Under Development 5 72.44 Quite High
Arrhythmias 2 Under Development 4 5.00 Very Low Very Low Very Low
Heart Disease 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Embryonic Lethality 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the severe AV block in the absence of atrial or ventricular arrhythmia mimicked in the Cx45 KO, we hypothesized that CAR (as described for N-cadherin; reference 6) affects electrical conduction indirectly through gap junctions.
CAR Regulation (affects) of Gene_expression (junctions) of gap in CAR associated with targeted disruption and arrhythmia under development
1) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 1.04 Pain Relevance 0.04

General Comments

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