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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 68
Total Number 72
Disease Relevance 45.48
Pain Relevance 11.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
B cells 4
leucocyte 3
T cell 3
liver 2
pleura 2
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 30 99.92 Very High Very High Very High
Inflammation 331 99.56 Very High Very High Very High
Inflammatory marker 21 99.48 Very High Very High Very High
Arthritis 491 99.12 Very High Very High Very High
cytokine 298 99.04 Very High Very High Very High
Inflammatory mediators 7 97.88 Very High Very High Very High
rheumatoid arthritis 220 97.34 Very High Very High Very High
Angina 35 96.36 Very High Very High Very High
Spinal cord 4 87.80 High High
chemokine 41 87.52 High High
Disease Link Frequency Relevance Heat
Adhesions 53 100.00 Very High Very High Very High
Urticaria 5 100.00 Very High Very High Very High
Coronary Artery Disease 50 99.82 Very High Very High Very High
Disease 347 99.80 Very High Very High Very High
Peripheral Arterial Disease 7 99.80 Very High Very High Very High
Infection 270 99.78 Very High Very High Very High
INFLAMMATION 360 99.68 Very High Very High Very High
Metabolic Syndrome 39 99.64 Very High Very High Very High
Syndrome 70 99.48 Very High Very High Very High
Atherosclerosis 77 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inflammatory processes that are shared by SLE and atherosclerotic disease include immune complex deposition and fixation, autoantibody binding, complement activation and CD40-CD40 ligand interaction.
CD40-CD40 Binding (interaction) of associated with inflammation, atherosclerosis, disease and systemic lupus erythematosus
1) Confidence 0.47 Published 2006 Journal Autoimmun Rev Section Abstract Doc Link 16431336 Disease Relevance 2.14 Pain Relevance 0.28
Antibodies binding gangliosides IgM class GM-1, GDA-1 and GM-2 were positive.
IgM Binding (binding) of
2) Confidence 0.47 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2912254 Disease Relevance 1.20 Pain Relevance 0.11
Schnitzler's syndrome (SS) is characterized by the association of generalized chronic urticaria, osteocondensation and monoclonal IgM gammopathy.
IgM Binding (association) of associated with urticaria and syndrome
3) Confidence 0.47 Published 2002 Journal Dermatology (Basel) Section Abstract Doc Link 12145435 Disease Relevance 0.74 Pain Relevance 0.17
By univariate analysis, age greater than 60, diffuse pattern, stage IV disease, involvement of liver, lung, pleura, or g-i tract, 'B' symptoms, surface heavy chain IgM or IgM-D, and LDH greater than 200 IU/dl were found to be significantly associated with a poor prognosis.
IgM-D Binding (associated) of in pleura associated with disease
4) Confidence 0.37 Published 1989 Journal Hematol Oncol Section Abstract Doc Link 2475420 Disease Relevance 0.77 Pain Relevance 0.08
Inflammatory processes that are shared by SLE and atherosclerotic disease include immune complex deposition and fixation, autoantibody binding, complement activation and CD40-CD40 ligand interaction.
CD40-CD40 Binding (interaction) of associated with inflammation, atherosclerosis, disease and systemic lupus erythematosus
5) Confidence 0.37 Published 2006 Journal Autoimmun Rev Section Abstract Doc Link 16431336 Disease Relevance 2.14 Pain Relevance 0.28
Patients with arthritis as revealed by chart review or baseline physical examination, a negative ACPA and IgM-RF status on second analysis, previous treatment with a disease-modifying antirheumatic drug (DMARD) or recent glucocorticoid treatment (<3 months) were excluded.
IgM Spec (examination) Binding (negative) of associated with disease and arthritis
6) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911885 Disease Relevance 1.04 Pain Relevance 0.45
Monoclonal IgM/lambda gammopathy with anti-myelin and anti-nucleo reactivity, found with serum immunofixation, were confirmed several times in successive annual controls, not associated to myeloproliferative pathology.
IgM Binding (associated) of
7) Confidence 0.36 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 12866587 Disease Relevance 0.64 Pain Relevance 0.16
The presence of metabolic syndrome is independently associated with elevated serum CD40 ligand and disease severity in patients with symptomatic coronary artery disease.
CD40 ligand Binding (associated) of in coronary artery associated with coronary artery disease, metabolic syndrome, disease and cytokine
8) Confidence 0.36 Published 2006 Journal Metab. Clin. Exp. Section Title Doc Link 16839837 Disease Relevance 1.15 Pain Relevance 0.13
Patients were assessed on admission: clinical characteristics, ECG (electrocardiogram), renal function, cardiac troponin T (cTnT), heart fatty acid binding protein (H-FABP), glycogen phosphorylase-BB, NT-pro-brain natriuretic peptide, D-dimer, hsCRP (high sensitivity C-reactive protein), myeloperoxidase, matrix metalloproteinase-9, pregnancy associated plasma protein-A, soluble CD40 ligand.
CD40 ligand Binding (binding) of in heart
9) Confidence 0.36 Published 2008 Journal Eur. Heart J. Section Body Doc Link 18682444 Disease Relevance 0.17 Pain Relevance 0
No significant differences were observed in any of the vascular adhesion markers, hsCRP, HgA1c, and sCD40L (data not shown).


CD40L Binding (any) of associated with adhesions
10) Confidence 0.36 Published 2010 Journal Nutr J Section Body Doc Link PMC2841082 Disease Relevance 0.32 Pain Relevance 0
By univariate analysis, age greater than 60, diffuse pattern, stage IV disease, involvement of liver, lung, pleura, or g-i tract, 'B' symptoms, surface heavy chain IgM or IgM-D, and LDH greater than 200 IU/dl were found to be significantly associated with a poor prognosis.
IgM Binding (associated) of in pleura associated with disease
11) Confidence 0.36 Published 1989 Journal Hematol Oncol Section Abstract Doc Link 2475420 Disease Relevance 0.77 Pain Relevance 0.08
After reaction with DAB, the sections were incubated with a second primary antibody for 1 hour, followed by incubation with ALP-conjugated IgG or IgM for 40 minutes.
IgM Binding (incubation) of
12) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0 Pain Relevance 0.03
Our correlation analyses showed significant association between sCD154 and the pro-inflammatory markers IL6, IL1 ?
sCD154 Binding (association) of associated with inflammatory marker
13) Confidence 0.36 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.25 Pain Relevance 0.64
We speculate that sCD154 could possibly interact with cells bearing CD40, possibly enhancing antigen presentation, and production of other inflammatory mediators in JIA.
sCD154 Binding (interact) of associated with inflammatory mediators and arthritis
14) Confidence 0.36 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.28 Pain Relevance 0.59
Orbital fibroblasts in particular are neural crest derived17 and express CD40 (a typical B-cell cell surface receptor) that can be activated by T-cell receptor (CD154) linkage to elicit inflammatory cytokines and bone marrow derived cell migration factors.18,19
CD154 Binding (linkage) of in T-cell associated with inflammation and cytokine
15) Confidence 0.35 Published 2006 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2908832 Disease Relevance 0.60 Pain Relevance 0.18
Furthermore, an anti-CD154 antibody, IDEC-131 (a humanized antibody that blocks CD40-CD154 interactions [31]), was well tolerated in a phase II study conducted in 85 patients with mild-to-moderate SLE [32]; however, it failed to meet the primary efficacy end-point, namely a reduction in SLEDAI score at 20 weeks after six infusions of IDEC-131 ranging from 2.5 to 10 mg/kg.
CD154 Binding (interactions) of associated with systemic lupus erythematosus
16) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.69 Pain Relevance 0.06
METHODS AND RESULTS: To study the role of CD40L-CD40 interaction in coronary disease, we analyzed levels of soluble (s) and membrane-bound CD40L in the peripheral blood from 29 patients with stable angina, 26 with unstable angina, and 19 controls.
CD40L-CD40 Binding (interaction) of in blood
17) Confidence 0.34 Published 1999 Journal Circulation Section Body Doc Link 10441098 Disease Relevance 0.29 Pain Relevance 0
Human blood B cells highly express Cox-2 mRNA and protein and produce PGs after activation with CD40L, pansorbin, or CD40L plus BCR engagement.
CD40L Binding (engagement) of in B cells
18) Confidence 0.33 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.37 Pain Relevance 0.42
Human blood B cells highly express Cox-2 mRNA and protein and produce PGs after activation with CD40L, pansorbin, or CD40L plus BCR engagement.
CD40L Binding (engagement) of in B cells
19) Confidence 0.33 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.38 Pain Relevance 0.43
The propensity of APM to inhibit IgM RF binding was assessed by competitive enzyme immunoassays with solid-phase human IgG.
IgM Binding (binding) of
20) Confidence 0.32 Published 1999 Journal J. Mol. Recognit. Section Abstract Doc Link 10440996 Disease Relevance 0.50 Pain Relevance 0.29

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