INT248304

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.39
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
nucleus 2
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 5 99.30 Very High Very High Very High
Desipramine 2 98.78 Very High Very High Very High
antidepressant 43 98.38 Very High Very High Very High
Inflammation 12 89.84 High High
depression 77 88.56 High High
adenocard 3 88.08 High High
Arthritis 2 84.60 Quite High
long-term potentiation 10 71.92 Quite High
Hippocampus 3 56.52 Quite High
Osteoarthritis 44 53.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 89.84 High High
Depression 94 88.56 High High
Anxiety Disorder 22 87.36 High High
Arthritis 2 84.60 Quite High
Stress 9 74.80 Quite High
Necrosis 1 68.48 Quite High
Cancer 1 68.12 Quite High
Osteoarthritis 22 53.28 Quite High
Disease 20 52.72 Quite High
Pain 55 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the components of CRx-102 affect the activity of key transcription factors, but not their nuclear localisation nor does it increase glucocorticoid receptor translocation or transcription from positive glucocorticoid response element promoters relative to low dose prednisolone on its own.22 Dipyridamole may contribute to the action of CRx-102 by increasing cAMP in part though inhibition of phosphodiesterases relevant to inflammation, as well as through modulating adenosine transport resulting in increased extra-cellular endogenous adenosine.34 Adenosine can suppress the release of TNF?
Neg (nor) Positive_regulation (increase) of Localization (translocation) of glucocorticoid receptor associated with adenocard and inflammation
1) Confidence 0.10 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564788 Disease Relevance 0.58 Pain Relevance 0.35
Milnacipran, in common with other antidepressants such as desipramine, clomipramine, fluoxetine and clorgyline, has been shown to induce a rapid and sustained translocation of the glucocorticoid receptor into the nucleus of human lymphocytes in vitro (Okuyama-Tamura et al 2003).


Positive_regulation (induce) of Localization (translocation) of glucocorticoid receptor in nucleus associated with desipramine, antidepressant and fluoxetine
2) Confidence 0.03 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654524 Disease Relevance 0.81 Pain Relevance 0.52

General Comments

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