INT248403

Context Info Confidence 0.40 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 11 Disease Relevance 7.77 Pain Relevance 0.14

nucleolus (CDKN1C) nucleus (CDKN1C) cell cycle (CDKN1C) cytoplasm (CDKN1C)

Anatomy Link Frequency hip 4 knee 3 joint 2 angular 2 extremity 2 CDKN1C (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 44 63.84 Spinal cord 33 58.60 Pain 11 43.16 backache 11 37.24 Multiple sclerosis 11 11.88

Disease Link Frequency Relevance Heat Beckwith-wiedemann Syndrome 836 100.00 Aging 143 97.00 Body Weight 143 94.12 Injury 22 86.16 Stroke 44 63.52 Pain 11 43.16 Low Back Pain 11 37.24 Anxiety Disorder 11 33.72 Spinal Cord Injury 22 31.28 Disease 11 28.72

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.

Positive_regulation (increased) of Gene_expression (levels) of BWS in angular associated with beckwith-wiedemann syndrome

1) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 1.03 Pain Relevance 0

At higher levels of BWS, a reduction of force at the knee might have resulted in less knee involvement.

Positive_regulation (levels) of Gene_expression (levels) of BWS in knee associated with beckwith-wiedemann syndrome

2) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.82 Pain Relevance 0

Therefore, the purpose of this study was to determine the kinematic variability of the lower extremities in young and elderly healthy females at changing levels of BWS during walking.

Positive_regulation (changing) of Gene_expression (levels) of BWS associated with beckwith-wiedemann syndrome

3) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.67 Pain Relevance 0.03

Overall our results refuted our first hypothesis showing that increased levels of BWS resulted in increased variability.

Positive_regulation (increased) of Gene_expression (levels) of BWS associated with beckwith-wiedemann syndrome

4) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.77 Pain Relevance 0

It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.

Positive_regulation (increased) of Gene_expression (levels) of BWS in hip associated with beckwith-wiedemann syndrome

5) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.51 Pain Relevance 0.03

The purpose of this study was to determine the kinematic variability of the lower extremities in young and elderly healthy females at changing levels of BWS during walking.

Positive_regulation (changing) of Gene_expression (levels) of BWS associated with beckwith-wiedemann syndrome

6) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 1.17 Pain Relevance 0

Increased levels of BWS resulted in increased linear and nonlinear measures of joint kinematic variability.

Positive_regulation (Increased) of Gene_expression (levels) of BWS in joint associated with beckwith-wiedemann syndrome

7) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.52 Pain Relevance 0.03

In order to minimize the vest shifting up the torso with increased levels of BWS, air was hand-pumped into the right and left chambers of the vest until it was comfortably tight.

Positive_regulation (increased) of Gene_expression (levels) of BWS associated with beckwith-wiedemann syndrome

8) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.42 Pain Relevance 0

Increased levels of BWS increased lower extremity kinematic variability.

Positive_regulation (Increased) of Gene_expression (levels) of BWS in extremity associated with beckwith-wiedemann syndrome

9) Confidence 0.40 Published 2008 Journal J Neuroeng Rehabil Section Abstract Doc Link PMC2564959 Disease Relevance 0.84 Pain Relevance 0

It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.

Positive_regulation (increased) of in ankle joints Gene_expression (levels) of BWS in hip associated with beckwith-wiedemann syndrome

10) Confidence 0.14 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.51 Pain Relevance 0.03

It was hypothesized that increased levels of BWS would decrease both linear and nonlinear measures of angular kinematic variability of the hip, knee and ankle joints.

Positive_regulation (increased) of in knee Gene_expression (levels) of BWS in hip associated with beckwith-wiedemann syndrome

11) Confidence 0.14 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2564959 Disease Relevance 0.51 Pain Relevance 0.03

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