INT24880

Context Info Confidence 0.69 First Reported 1982 Last Reported 1996 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 1.34 Pain Relevance 2.74

plasma membrane (HRH2) signal transducer activity (HRH2)

HRH2 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 18 100.00 Bioavailability 4 100.00 cINOD 12 99.98 agonist 5 96.88 tricyclic antidepressant 8 95.36 depression 1 92.32 Clonidine 3 90.20 peptic ulcer disease 3 83.04 fluoxetine 1 58.00 anesthesia 2 43.28

Disease Link Frequency Relevance Heat Bronchogenic Carcinoma 3 96.92 Depression 1 92.32 Hypersensitivity 2 89.24 Ulcers 5 89.16 Adverse Drug Reaction 1 88.20 Wheal 1 83.36 Disease 3 83.04 INFLAMMATION 2 80.04 Cancer 3 55.44 Peptic Ulcer 1 50.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results show that NSAIDs increased the bioavailability of H2-receptor antagonists, and that the latter drugs decrease the volume of distribution of NSAIDs.

Positive_regulation (increased) of H2-receptor associated with antagonist, cinod and bioavailability

1) Confidence 0.69 Published 1988 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2901930 Disease Relevance 0.05 Pain Relevance 0.75

Urinary data and observed modifications in ranitidine and cimetidine metabolites seem to justify a greater increase of H2-receptor antagonist bioavailability with indomethacin (p less than 0.05) than with sulindac (NS).

Positive_regulation (increase) of H2-receptor associated with antagonist and bioavailability

2) Confidence 0.69 Published 1988 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2901930 Disease Relevance 0.08 Pain Relevance 0.54

In addition to their well-known anticholinergic properties, in vitro studies have indicated potent H1- and H2-receptor blocking activities for these agents.

Positive_regulation (indicated) of H2-receptor

3) Confidence 0.50 Published 1984 Journal Arch. Intern. Med. Section Abstract Doc Link 6367680 Disease Relevance 0.58 Pain Relevance 0.61

Ranitidine is a potent inhibitor of gastric acid secretion whose chemical structure lacks the imidazole group previously believed to be essential for H2-receptor blocking activity.

Positive_regulation (essential) of H2-receptor

4) Confidence 0.41 Published 1982 Journal Clin Pharm Section Abstract Doc Link 6309467 Disease Relevance 0.14 Pain Relevance 0.08

The H2-receptor antagonists, cimetidine and ranitidine, increased Td. 3.

Positive_regulation (increased) of H2-receptor associated with antagonist

5) Confidence 0.35 Published 1996 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8800567 Disease Relevance 0.23 Pain Relevance 0.40

This reduction in hepatic drug metabolism could be due to cimetidine's intrinsic H2-receptor blocking activity.

Positive_regulation (due) of H2-receptor

6) Confidence 0.32 Published 1982 Journal Gastroenterology Section Abstract Doc Link 6118314 Disease Relevance 0 Pain Relevance 0.07

H2 receptor stimulation seems to be responsible for the reduction in histamine release observed, since it can be antagonized by cimetidine, but not by alpha 1, alpha 2 and H1 blockers.

Positive_regulation (stimulation) of H2 receptor

7) Confidence 0.16 Published 1989 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2478489 Disease Relevance 0.26 Pain Relevance 0.29

General Comments

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