INT24895

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 17.92
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LYZ) hydrolase activity, acting on glycosyl bonds (LYZ) extracellular region (LYZ)
Anatomy Link Frequency
eosinophils 2
neutrophil 2
nociceptor 1
feces 1
granulocyte 1
LYZ (Homo sapiens)
Pain Link Frequency Relevance Heat
nociceptor 1 99.16 Very High Very High Very High
Inflammation 268 98.84 Very High Very High Very High
Inflammatory mediators 48 98.36 Very High Very High Very High
depression 1 97.28 Very High Very High Very High
Inflammatory response 26 95.16 Very High Very High Very High
spastic colon 25 94.20 High High
Angina 1 93.76 High High
Pain 15 91.72 High High
headache 9 89.12 High High
cINOD 7 88.04 High High
Disease Link Frequency Relevance Heat
Otitis Media With Effusion 184 99.84 Very High Very High Very High
Cancer 96 99.78 Very High Very High Very High
Inflammatory Bowel Disease 118 99.32 Very High Very High Very High
Hypersensitivity 29 99.08 Very High Very High Very High
INFLAMMATION 329 98.84 Very High Very High Very High
Otitis Media 268 98.36 Very High Very High Very High
Pleural Effusion 2 98.20 Very High Very High Very High
Bacterial Infection 8 98.04 Very High Very High Very High
Histiocytic Sarcoma 99 97.84 Very High Very High Very High
Interdigitating Dendritic Cell Sarcoma 12 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Eugenol was also able to enhance the activities of lysozyme, Triton X-100 and SDS in damaging the bacterial cell membrane.
Positive_regulation (enhance) of lysozyme
1) Confidence 0.70 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19540744 Disease Relevance 0.31 Pain Relevance 0.20
The level of serum angiotensin-converting enzyme was normal, but that of lysozyme was elevated.
Positive_regulation (elevated) of lysozyme
2) Confidence 0.65 Published 2007 Journal Intern. Med. Section Abstract Doc Link 17827852 Disease Relevance 0.54 Pain Relevance 0.09
Serum angiotensin-II-converting enzyme and lysozyme levels were elevated.
Positive_regulation (elevated) of lysozyme
3) Confidence 0.64 Published 2002 Journal Intern. Med. Section Abstract Doc Link 12487182 Disease Relevance 0.85 Pain Relevance 0.09
Leukocyte counts or albumin and lysozyme levels were not significantly increased after administration of 1 microg of capsaicin at any time point.
Neg (not) Positive_regulation (increased) of lysozyme in Leukocyte
4) Confidence 0.64 Published 1997 Journal J. Allergy Clin. Immunol. Section Body Doc Link 9389293 Disease Relevance 0.06 Pain Relevance 0
Serum levels of soluble IL-2 receptor and lysozyme were increased, and a significant uptake was observed by Ga scintigraphy at the nasopharynx and bilateral hilar lymphnodes.
Positive_regulation (increased) of lysozyme in nasopharynx
5) Confidence 0.53 Published 2001 Journal Nihon Rinsho Meneki Gakkai Kaishi Section Abstract Doc Link 11280897 Disease Relevance 0.88 Pain Relevance 0.09
A lymphocyte stimulation test (LST) with the patient's peripheral lymphocytes strongly suggested that the eruption was attributable to lysozyme chloride which was included in the preparation taken.
Positive_regulation (attributable) of lysozyme in lymphocytes
6) Confidence 0.44 Published 2000 Journal J. Dermatol. Section Abstract Doc Link 10920587 Disease Relevance 0.78 Pain Relevance 0.09
Albumin and lysozyme levels were both significantly increased 30 minutes after 10 microg and 100 microg of capsaicin (p = 0.005 for both).
Positive_regulation (increased) of lysozyme
7) Confidence 0.43 Published 1997 Journal J. Allergy Clin. Immunol. Section Body Doc Link 9389293 Disease Relevance 0 Pain Relevance 0
G-CSF-induced neutrophils exhibited an increased O2- radical production, and serum levels of enzymes related to granulocyte turnover, including lysozyme and elastase, were markedly elevated during therapy.
Positive_regulation (elevated) of lysozyme in granulocyte
8) Confidence 0.38 Published 1989 Journal Blood Section Abstract Doc Link 2479425 Disease Relevance 0.49 Pain Relevance 0.13
The granular cells of the current case were positive for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD 68, lysozyme, and alpha-1-antitrypsin.
Positive_regulation (positive) of lysozyme in neuron
9) Confidence 0.17 Published 2008 Journal Neuropathology Section Abstract Doc Link 18466222 Disease Relevance 0.89 Pain Relevance 0.08
The tuberculin reaction was negative, and elevation of serum lysozyme and IgG level were seen.
Positive_regulation (elevation) of serum lysozyme
10) Confidence 0.15 Published 2007 Journal Clin Neurol Neurosurg Section Abstract Doc Link 17651894 Disease Relevance 0.58 Pain Relevance 0.14
In allergic dogs in vivo, NPC 15669 (10(-5) M) prevented antigen-induced recruitment of eosinophils and neutrophils and prevented the increase in elastase and lysozyme concentrations.
Positive_regulation (increase) of lysozyme in eosinophils associated with hypersensitivity
11) Confidence 0.14 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.32 Pain Relevance 0.10
The latter consistently expresses S-100 protein, ATPase and HLA-DR, and is variably, weakly positive for CD68, lysozyme, and CD45 [1,5-8].
Positive_regulation (positive) of lysozyme
12) Confidence 0.11 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.10 Pain Relevance 0
These cells were histochemistrically negative for myeloperoxidase and naphtol-ASD-chloroacetate esterase, and were also negative for lysozyme, cytokeratin 7, 9, 20, EMA, CEA, CD3, CD79a on immunohistochemistry, but were positive for CD43, CD56.
Positive_regulation (positive) of lysozyme
13) Confidence 0.10 Published 2003 Journal Nippon Ronen Igakkai Zasshi Section Abstract Doc Link 12708054 Disease Relevance 1.68 Pain Relevance 0.14
They were strongly positive for CD163 (Fig. 4), CD68, lysozyme, NSE, and vimentin.
Positive_regulation (positive) of lysozyme
14) Confidence 0.10 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.33 Pain Relevance 0
Immunohistochemical staining in the tumor cells was positive for CD163, CD68, lysozyme, CD45, and NSE.
Positive_regulation (positive) of lysozyme associated with cancer
15) Confidence 0.10 Published 2007 Journal Diagn Pathol Section Abstract Doc Link PMC1808440 Disease Relevance 0.86 Pain Relevance 0
Blinking frequency and the lavage biomarkers myeloperoxidase and lysozyme were significantly increased, and forced vital capacity was significantly decreased during exposure to 3-MF compared with air control.
Positive_regulation (increased) of lysozyme
16) Confidence 0.09 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1314919 Disease Relevance 0.08 Pain Relevance 0
Then, we examined the effect of NPC 15669 on antigen-induced eosinophil and neutrophil recruitment and subsequent airway hypersecretion (indicated by an increase in lysozyme concentration) in the allergic dog trachea in vivo.
Positive_regulation (increase) of lysozyme in eosinophil associated with hypersensitivity
17) Confidence 0.08 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.33 Pain Relevance 0.13
These results suggest that a DNA damage-induced lysozyme may target susceptible cells in culture and provide a source of DNA for uptake.
Positive_regulation (induced) of lysozyme
18) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2912397 Disease Relevance 0 Pain Relevance 0
In allergic dogs in vivo, NPC 15669 (10(-5) M) prevented antigen-induced recruitment of eosinophils and neutrophils and prevented the increase in elastase and lysozyme concentrations.
Positive_regulation (increase) of lysozyme in neutrophils associated with hypersensitivity
19) Confidence 0.05 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.32 Pain Relevance 0.10
Immunohistochemistry is variable, but in most cases, staining is positive for CD68, CD4, CD45, HLA-DR, and lysozyme, but negative for S100, CD20, and factor XIIIa [7].
Positive_regulation (positive) of lysozyme
20) Confidence 0.05 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.06 Pain Relevance 0.11

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