INT249002

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per1) transport (Gabrg1) nucleus (Per1)
protein binding transcription factor activity (Per1) plasma membrane (Gabrg1) cytoplasm (Per1)
Anatomy Link Frequency
amacrine cells 2
Gabrg1 (Mus musculus)
Per1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 258 100.00 Very High Very High Very High
GABAergic 26 100.00 Very High Very High Very High
Neurotransmitter 46 88.72 High High
Dopamine 150 78.96 Quite High
agonist 56 57.04 Quite High
Glutamate receptor 4 47.32 Quite Low
GABA receptor 18 35.96 Quite Low
antagonist 56 5.00 Very Low Very Low Very Low
Glutamate 26 5.00 Very Low Very Low Very Low
Action potential 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 52 94.24 High High
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Myopia 2 5.00 Very Low Very Low Very Low
Dislocations 2 5.00 Very Low Very Low Very Low
Refractive Errors 2 5.00 Very Low Very Low Very Low
Retina Disease 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Ocular Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that GABA could, through membrane hyperpolarization and activation of casein kinase, stimulate the degradation of accumulated PER proteins on the falling phase of their rhythm (which roughly corresponds to the night state), acting to remove feedback inhibition on Per transcription and thereby preparing retinal oscillators for transcriptional activation that characterizes the “day” state.
GABA Positive_regulation (stimulate) of Protein_catabolism (degradation) of PER associated with gaba
1) Confidence 0.35 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.67
In contrast, retinal GABA exhibits elevated turnover and release at night [21], perhaps from excitatory input from OFF bipolar cells to GABAergic amacrine cells, and in this model, stimulates the degradation of accumulated PER proteins through casein kinase activation, acting to remove feedback inhibition on Per transcription, and thereby preparing retinal oscillators for transcriptional activation in the next “day” state.
GABA Positive_regulation (stimulates) of Protein_catabolism (degradation) of PER in amacrine cells associated with gaba and gabaergic
2) Confidence 0.35 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.09 Pain Relevance 0.48

General Comments

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