INT249008

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per1) transport (Gabrg1) nucleus (Per1)
protein binding transcription factor activity (Per1) plasma membrane (Gabrg1) cytoplasm (Per1)
Gabrg1 (Mus musculus)
Per1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 129 100.00 Very High Very High Very High
Neurotransmitter 23 88.72 High High
GABAergic 13 84.88 Quite High
Dopamine 75 74.08 Quite High
Glutamate receptor 2 47.32 Quite Low
GABA receptor 9 35.96 Quite Low
agonist 28 5.00 Very Low Very Low Very Low
antagonist 28 5.00 Very Low Very Low Very Low
Glutamate 13 5.00 Very Low Very Low Very Low
Action potential 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 26 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Myopia 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Refractive Errors 1 5.00 Very Low Very Low Very Low
Retina Disease 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Ocular Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that GABA could, through membrane hyperpolarization and activation of casein kinase, stimulate the degradation of accumulated PER proteins on the falling phase of their rhythm (which roughly corresponds to the night state), acting to remove feedback inhibition on Per transcription and thereby preparing retinal oscillators for transcriptional activation that characterizes the “day” state.
GABA Regulation (degradation) of PER associated with gaba
1) Confidence 0.33 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.67

General Comments

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