INT24906

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Context Info
Confidence 0.40
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.48
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (SP1) nucleus (SP1) intracellular (SP1)
DNA binding (SP1) transcription factor binding (SP1) cytoplasm (SP1)
SP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 24 100.00 Very High Very High Very High
Cholecystokinin 7 96.96 Very High Very High Very High
Morphine 6 86.64 High High
abdominal pain 3 85.92 High High
addiction 3 85.92 High High
withdrawal 1 78.68 Quite High
analgesia 1 67.52 Quite High
agonist 8 62.32 Quite High
Neuropeptide 1 58.96 Quite High
Kinase C 94 58.36 Quite High
Disease Link Frequency Relevance Heat
Infection 15 99.54 Very High Very High Very High
Oligohydramnios 1 99.16 Very High Very High Very High
Tubal Pregnancy 10 98.52 Very High Very High Very High
Alcohol Addiction 3 92.84 High High
Immunodeficiency 9 92.64 High High
Ectopic Pregnancy 95 91.40 High High
Colon Cancer 2 88.28 High High
Repression 14 87.12 High High
Emergencies 5 86.56 High High
Abdominal Pain 3 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore concluded that aberrant methylation of the promoter and reduction of Sp1 resulting from SIVmac239 infection led to the silencing of the MOR gene.
Negative_regulation (reduction) of Sp1 associated with mu opioid receptor and infection
1) Confidence 0.40 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.61 Pain Relevance 0.32
The results of methylation-specific PCR showed that two of 14 CpG islands adjacent to the Sp1 and YY1 elements in the promoter region were methylated, which together with reduced Sp1, contributed to the failure of interaction of Sp1 with YY1 and their binding to the elements, as determined by coimmunoprecipitation, chromatin immunoprecipitation-real-time PCR, and EMSAs.
Negative_regulation (reduced) of Sp1
2) Confidence 0.40 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.75 Pain Relevance 0.35
In this study, it was demonstrated that SIV (SIVmac239) infection may result in gradual reduction of the MOR gene expression and Sp1 during a period of 48 h postinfection by analysis of quantitative real-time RT-PCR and Western blotting.
Negative_regulation (reduction) of Sp1 associated with mu opioid receptor and infection
3) Confidence 0.39 Published 2009 Journal J. Leukoc. Biol. Section Abstract Doc Link 19164126 Disease Relevance 0.71 Pain Relevance 0.36
A live fetus was demonstrated in 259 women of whom six subsequently miscarried; one of these had markedly depressed serum hCG and PAPP-A, but normal SP1 levels, and two had oligohydramnios.
Negative_regulation (depressed) of SP1 associated with oligohydramnios
4) Confidence 0.35 Published 1989 Journal Br J Obstet Gynaecol Section Abstract Doc Link 2480155 Disease Relevance 0.57 Pain Relevance 0.09
We demonstrate that substitution of the C-36 residue causes a slight reduction of Sp1 and Sp3 binding, but this has no effect on transcription in vivo.
Negative_regulation (reduction) of Sp1
5) Confidence 0.34 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889557 Disease Relevance 0.76 Pain Relevance 0.39
The authors measured PAPP-A, hCG, and SP1 concentrations in 164 serum samples and 29 tissue samples obtained from these women.
Negative_regulation (measured) of SP1
6) Confidence 0.30 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.86 Pain Relevance 0.08
directly interacts with the transcription factor Sp1 at the protein level leading to inhibition of Sp1 and thereby, the transcriptional down-regulation of Sp1 target genes [36,37].
Negative_regulation (inhibition) of Sp1
7) Confidence 0.26 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0.09
directly interacts with the transcription factor Sp1 at the protein level leading to inhibition of Sp1 and thereby, the transcriptional down-regulation of Sp1 target genes [36,37].
Negative_regulation (down-regulation) of Sp1
8) Confidence 0.26 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.09 Pain Relevance 0.09

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