INT249136

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.55
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Was) protein complex assembly (Was) cytoplasm (Was)
Anatomy Link Frequency
white blood cells 1
T cells 1
Was (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 60.68 Quite High
tolerance 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 99.64 Very High Very High Very High
Wiskott-aldrich Syndrome 54 98.32 Very High Very High Very High
Immunodeficiency 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Eczema 4 5.00 Very Low Very Low Very Low
Thrombocytopenia 4 5.00 Very Low Very Low Very Low
Hemorrhage 4 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 4 5.00 Very Low Very Low Very Low
Uveitis 2 5.00 Very Low Very Low Very Low
Immune System Diseases 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WASP, the gene product affected in this disease, is specific to white blood cells where it is responsible for regulating actin cytoskeleton dynamics in a wide range of cellular responses.
Regulation (affected) of WASP in white blood cells associated with disease
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2567846 Disease Relevance 0.37 Pain Relevance 0
This second selective event occurring in peripheral T cells has been described also for WAS patients with single somatic alleles (e.g., [9]), and is consistent with the known role of WASP in antigen receptor mediated (TCR-mediated) activation of naïve T cells [16], [38], [39].
Regulation (role) of WASP in T cells associated with wiskott-aldrich syndrome
2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2567846 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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