INT249332

Context Info Confidence 0.17 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.63 Pain Relevance 0.08

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR) endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)

GPNMB (Homo sapiens) EGFR (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 2 78.04 anesthesia 10 5.00 Central nervous system 8 5.00 ketamine 8 5.00 imagery 4 5.00 cytokine 2 5.00 Inflammation 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Cancer 2 99.50 Stress 2 94.72 Glaucoma 182 92.40 Ocular Hypertension 36 75.36 Eye Disease 2 72.08 Sprains And Strains 4 68.56 Syndrome 4 65.92 Frailty 4 60.08 Iris Diseases 2 51.36 Ganglion Cysts 46 49.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The latter has been underscored by roles for GPNMB in tumor invasion [98,99], where GPNMB promoted invasiveness through MMPs and also induced activation of epidermal growth factor receptor (EGFR) [80].

GPNMB Positive_regulation (activation) of epidermal growth factor receptor associated with cancer

1) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 1.31 Pain Relevance 0.04

The latter has been underscored by roles for GPNMB in tumor invasion [98,99], where GPNMB promoted invasiveness through MMPs and also induced activation of epidermal growth factor receptor (EGFR) [80].

GPNMB Positive_regulation (activation) of EGFR associated with cancer

2) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 1.32 Pain Relevance 0.04

General Comments

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