INT249342

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2009
Negated 4
Speculated 3
Reported most in Body
Documents 3
Total Number 45
Disease Relevance 16.71
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TYROBP) plasma membrane (TYROBP) intracellular (TYROBP)
Anatomy Link Frequency
NK cells 10
leukocytes 6
T cells 4
B cells 3
Dendritic cells 2
TYROBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 260 99.72 Very High Very High Very High
cytokine 88 96.96 Very High Very High Very High
Pain 43 80.52 Quite High
Sicca syndrome 43 50.72 Quite High
Rheumatism 43 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 1462 99.84 Very High Very High Very High
INFLAMMATION 215 99.72 Very High Very High Very High
Disease 264 98.28 Very High Very High Very High
Acute Myeloid Leukemia 43 98.12 Very High Very High Very High
Glaucoma 182 96.00 Very High Very High Very High
Dementia 43 95.60 Very High Very High Very High
Encephalitis 43 95.08 Very High Very High Very High
Syndrome 133 93.72 High High
Ganglion Cysts 46 84.48 Quite High
Hypercalcemia 43 82.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that an as yet unidentified adaptor molecule could associate with and stabilize cell surface expression of activating KIR in T cells that do not express DAP12.
Neg (not) Gene_expression (express) of DAP12 in T cells
1) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.31 Pain Relevance 0.15
However, data about DAP12 expression in humans relies on Western blot and microarrays studies.
Gene_expression (expression) of DAP12
2) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.14 Pain Relevance 0
T cells that express both DAP12 and activating KIR (Killer-cell Ig-like Receptor) have been described in patients suffering from chronic inflammatory diseases [6], [7].
Gene_expression (express) of DAP12 in T cells associated with inflammation and disease
3) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.29 Pain Relevance 0.14
Although initially described in NK cells, DAP12 expression has been reported in various hematopoietic cells such as osteoclasts, neutrophils, macrophages and dendritic cells [4].
Gene_expression (expression) of DAP12 in hematopoietic cells
4) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.22 Pain Relevance 0.13
This F4 mAb can be also used to detect DAP12 in Western-Blot as well as in immunohistochemistry assays (data not shown).


Gene_expression (detect) of DAP12
5) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.23 Pain Relevance 0
Since the original description of DAP12 expression in NK cells, a broader expression among other immune cells has also been found in mouse and human, both in myeloid and lymphoid cells, and many DAP12-associated activating membrane receptors have been described.
Gene_expression (expression) of DAP12 in immune cells
6) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.22 Pain Relevance 0
By contrast DAP12 expression was detected in the NK cell population with no difference between CD56bright and CD56dim sub-populations (Figure 2B).
Gene_expression (expression) of DAP12 in NK cell
7) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.06 Pain Relevance 0
This prompted us to extend on leukocyte subsets the analysis of DAP12 expression in SLE.
Gene_expression (expression) of DAP12 in leukocyte associated with systemic lupus erythematosus
8) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.75 Pain Relevance 0
DAP-12 expression pattern in healthy and systemic lupus erythematosus patients
Gene_expression (expression) of DAP-12 associated with systemic lupus erythematosus
9) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.23 Pain Relevance 0
The combination of neurological, bone and inflammatory disorders which are associated with an alteration of DAP12 expression prompted us to generate a reagent compatible with diverse immunodetection procedures.
Gene_expression (expression) of DAP12 associated with inflammation
10) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.87 Pain Relevance 0.21
It was previously described by western-blot analysis a down-regulation of DAP12 expression in NK cells from SLE patients.
Gene_expression (expression) of DAP12 in NK cells associated with systemic lupus erythematosus
11) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.71 Pain Relevance 0
In addition, DAP12 is also expressed by other leukocytes such as DC which have been clearly involved in lupus physiopathogeny.
Gene_expression (expressed) of DAP12 in leukocytes associated with systemic lupus erythematosus
12) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.76 Pain Relevance 0
Thus, the F4 mAb was used to provide additional data about the expression of the polypeptide DAP12 in leukocytes from healthy individuals.
Gene_expression (expression) of DAP12 in leukocytes
13) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.08 Pain Relevance 0
In mice, LPS-stimulated B cells express DAP12 in association with the immunoglobulin-like receptor II (MAIR-II) [8], [9].
Gene_expression (express) of DAP12 in B cells
14) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.29 Pain Relevance 0.13
Interestingly, some T and B cell subsets also express DAP12 under inflammatory conditions.
Gene_expression (express) of DAP12 in B cell associated with inflammation
15) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.27 Pain Relevance 0.14
Surprisingly, although the expression of ITAM-bearing adaptors is crucial to the expression of various activating immunoreceptors, some DAP12-negative T cells can express activating KIR [10].
Gene_expression (express) of DAP12 in T cells
16) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.32 Pain Relevance 0.15
Conversely, there is no significant modulation of the MFI for DAP12 expression by NK cells (Table 2).
Gene_expression (expression) of DAP12 in NK cells
17) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.67 Pain Relevance 0
The expression of DAP12 in other cells involved in innate immunity and expressing several DAP12-associated receptors was then evaluated (Figure 2C).
Gene_expression (expression) of DAP12
18) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.06 Pain Relevance 0
The expression of DAP12 in other cells involved in innate immunity and expressing several DAP12-associated receptors was then evaluated (Figure 2C).
Gene_expression (expressing) of DAP12
19) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.06 Pain Relevance 0
The expression of DAP12 in DCs, monocytes and neutrophils are similar in the two groups (Table 2).


Gene_expression (expression) of DAP12 in monocytes
20) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.62 Pain Relevance 0

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