INT249347

Context Info Confidence 0.19 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 6.15 Pain Relevance 0.89

nucleoplasm (FOS, JUN) aging (FOS, JUN) nucleus (FOS, JUN) cytosol (JUN) nuclear chromosome (JUN) nucleolus (FOS)

Anatomy Link Frequency apoptotic cell 2 FOS (Homo sapiens) JUN (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 6 93.76 cytokine 39 88.08 Arthritis 212 83.92 Inflammation 44 80.48 metalloproteinase 8 76.96 Neuronal nitric oxide synthase 8 64.16 chemokine 4 60.56 Inflammatory response 9 30.72 Inflammatory stimuli 2 24.52 dexamethasone 14 5.00

Disease Link Frequency Relevance Heat Hypoxia 64 98.04 Hepatitis C Virus Infection 6 97.20 Cirrhosis 8 93.76 Apoptosis 27 91.88 Death 8 91.28 Fibrosis 4 87.08 Stress 24 85.92 Disease 30 85.12 Rheumatoid Arthritis 206 83.92 Infection 5 83.32

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FOS is an example of an immediate early gene, it complexes with JUN to form the activator protein-1 transcription factor complex (AP-1) which regulates gene expression in response to hypoxia, and it has been known to be associated with regulation of cell cycle activities such as cell proliferation, differentiation, transformation, and apoptotic cell death [30].

AP-1 Binding (complexes) of JUN in apoptotic cell associated with hypoxia, apoptosis and death

1) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2567989 Disease Relevance 1.19 Pain Relevance 0.06

The AP-1 transcription factor is mainly composed of Jun, Fos, and/or ATF protein heterodimers.

AP-1 Binding (composed) of Jun

2) Confidence 0.17 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.60 Pain Relevance 0.15

FOS is an example of an immediate early gene, it complexes with JUN to form the activator protein-1 transcription factor complex (AP-1) which regulates gene expression in response to hypoxia, and it has been known to be associated with regulation of cell cycle activities such as cell proliferation, differentiation, transformation, and apoptotic cell death [30].

FOS Binding (complexes) of JUN in apoptotic cell associated with hypoxia, apoptosis and death

3) Confidence 0.17 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2567989 Disease Relevance 1.19 Pain Relevance 0.06

FOS is one of the leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.

FOS Binding (dimerize) of JUN

4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.08 Pain Relevance 0.33

FOS is one of the leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.

AP-1 Binding (dimerize) of JUN

5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.08 Pain Relevance 0.28

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