INT249504

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
spinal cord 1
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 56 99.84 Very High Very High Very High
Eae 20 98.72 Very High Very High Very High
Spinal cord 60 96.32 Very High Very High Very High
Glutamate 6 77.72 Quite High
Hippocampus 10 71.48 Quite High
Inflammation 18 50.00 Quite Low
Thermal hyperalgesia 26 18.64 Low Low
Hyperalgesia 22 15.92 Low Low
intrathecal 32 14.04 Low Low
Dorsal horn 22 7.04 Low Low
Disease Link Frequency Relevance Heat
Nociception 28 99.50 Very High Very High Very High
Inflammatory Pain 14 98.72 Very High Very High Very High
Congenital Anomalies 2 59.56 Quite High
Targeted Disruption 4 58.08 Quite High
INFLAMMATION 18 50.00 Quite Low
Hyperalgesia 50 18.64 Low Low
Neuropathic Pain 36 5.00 Very Low Very Low Very Low
Pain 26 5.00 Very Low Very Low Very Low
Ganglion Cysts 10 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence exists for a role at least of Fyn and Src in NMDA receptor phosphorylation (Salter and Kalia, 2004), therefore we cannot exclude that a combination of at least these two Src family kinases is responsible for ephrinB2-mediated NR2B phosphorylation in our spinal cord plasticity model.
Localization (least) of Src in spinal cord associated with nmda receptor and spinal cord
1) Confidence 0.36 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.22 Pain Relevance 0.29
The pro-nociceptive effects of ephrinB2 are mediated by Src-family kinases
Localization (mediated) of Src associated with nociception
2) Confidence 0.36 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.10 Pain Relevance 0.16

General Comments

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