INT249509

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.79
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fyn) endosome (Fyn) mitochondrion (Fyn)
plasma membrane (Fyn)
Anatomy Link Frequency
Nerve 1
Fyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 5 99.72 Very High Very High Very High
Glutamate 3 95.96 Very High Very High Very High
nMDA receptor 28 95.48 Very High Very High Very High
adenocard 7 95.48 Very High Very High Very High
Spinal cord 30 72.28 Quite High
Eae 11 70.64 Quite High
Somatostatin 2 68.64 Quite High
Hippocampus 14 68.16 Quite High
fluoxetine 11 51.48 Quite High
antidepressant 46 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 18 98.04 Very High Very High Very High
Necrosis 14 97.80 Very High Very High Very High
Alzheimer's Dementia 8 89.48 High High
Apoptosis 14 87.08 High High
Congenital Anomalies 1 77.80 Quite High
Targeted Disruption 2 76.32 Quite High
Inflammatory Pain 7 70.64 Quite High
INFLAMMATION 15 50.00 Quite Low
Hyperalgesia 25 36.88 Quite Low
Neuropathic Pain 19 10.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, treatment with phenelzine resulted in up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Fyn proto-oncogene), 14 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Leptin receptor, Adrenomedullin, Arrestin beta 1, Syntaxin 1A, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, Growth differentiation factor 15, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of four (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Phospholipase A2 activating protein, Tumor necrosis factor receptor superfamily member 6), three (Serum amyloid A 4, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after treatment for one, three and seven days, respectively (Table 1 and 2).
Gene_expression (expressed) of Fyn proto-oncogene in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and apoptosis
1) Confidence 0.35 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.57 Pain Relevance 0.25
They also showed that in HEK293T cells mutation of the Src-binding site on EphB2 or expression of a dominant negative of Fyn (inhibiting Src family kinases) disabled the phosphorylation of NR2B effect of ephrinB2 and the potentiation of NMDA receptor activity.
Gene_expression (expression) of Fyn associated with nmda receptor
2) Confidence 0.33 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.22 Pain Relevance 0.32

General Comments

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