INT249733

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 5.77
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgb6)
Anatomy Link Frequency
cleavage 3
femur 1
Itgb6 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 175 99.16 Very High Very High Very High
Cancer pain 5 98.16 Very High Very High Very High
Spontaneous pain 15 94.48 High High
withdrawal 40 83.96 Quite High
Brush evoked pain 20 83.12 Quite High
Neuropathic pain 5 27.04 Quite Low
ketamine 15 5.00 Very Low Very Low Very Low
imagery 15 5.00 Very Low Very Low Very Low
allodynia 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 40 99.96 Very High Very High Very High
Cancer 330 99.36 Very High Very High Very High
Pain 190 99.16 Very High Very High Very High
Cancer Pain 5 98.16 Very High Very High Very High
Prostate Cancer 105 96.16 Very High Very High Very High
Neuropathic Pain 30 83.12 Quite High
Prostatic Intraepithelial Neoplasia 20 78.88 Quite High
Lung Cancer 10 75.32 Quite High
Metastasis 35 73.24 Quite High
Carcinoma 5 59.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used a novel xenograft mouse model to directly determine if bone pain could be prevented by blocking the known cleavage of the A6 integrin adhesion receptor.
Protein_catabolism (cleavage) of A6 integrin in cleavage associated with pain and adhesions
1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2570216 Disease Relevance 1.57 Pain Relevance 0.52
These data indicate that cleavage of integrin A6 influenced the development of cancerinduced spontaneous and evoked pain associated with bone loss and fracture.
Protein_catabolism (cleavage) of integrin A6 in cleavage associated with pain
2) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570216 Disease Relevance 1.12 Pain Relevance 1.04
The A6 integrin subunit is cleaved in half at the tumor cell surface at specific amino acid residues resulting in loss of the beta barrel domain and leaving the rest of the receptor intact[12].
Protein_catabolism (cleaved) of A6 integrin associated with cancer
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570216 Disease Relevance 1.26 Pain Relevance 0.06
Behavioral analyses of spontaneous and evoked pain were determined 21 days following injection of PC3N-A6-WT or PC3N-A6-RR cells into the femur to evaluate the role of cleavage of A6 integrin on the development of spontaneous and evoked cancer pain behaviors.
Protein_catabolism (cleavage) of A6 integrin in femur associated with pain and cancer pain
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570216 Disease Relevance 0.81 Pain Relevance 0.46
Preventing cleavage of integrin A6 dramatically reduced bone loss and development of cancerinduced pain.
Protein_catabolism (cleavage) of integrin A6 in cleavage associated with pain
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570216 Disease Relevance 1.00 Pain Relevance 0.92

General Comments

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