INT249934

Context Info Confidence 0.20 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.19 Pain Relevance 0

aging (Nos1, Nos2) cytoplasm (Nos1, Nos2) cytosol (Nos1, Nos2) nucleus (Nos1, Nos2) mitochondrion (Nos1) peroxisome (Nos2)

Anatomy Link Frequency leucocytes 1 platelet 1 Nos1 (Rattus norvegicus) Nos2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 8 35.28 cva 6 5.00 narcan 2 5.00 cytokine 2 5.00 withdrawal 2 5.00 Morphine 2 5.00 Bioavailability 2 5.00 Inflammatory mediators 2 5.00 addiction 2 5.00

Disease Link Frequency Relevance Heat Adhesions 4 94.64 Injury 2 39.28 INFLAMMATION 10 35.28 Stress 4 25.88 Toxicity 2 19.28 Hematological Disease 8 5.00 Thrombocytopenia 6 5.00 Hemorrhage 6 5.00 Body Weight 4 5.00 Aplasia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both iNOS and cNOS (nNOS and eNOS) are involved in the compatible regulation of leucocyte recruitment, and iNOS-derived NO inhibits platelet aggregation and platelet and leucocytes adhesion in the microvasculature, modulates cytoskeletal function [reviewed in Ref. 52].

nNOS Regulation (involved) of iNOS in leucocytes associated with adhesions

1) Confidence 0.20 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.09 Pain Relevance 0

Both iNOS and cNOS (nNOS and eNOS) are involved in the compatible regulation of leucocyte recruitment, and iNOS-derived NO inhibits platelet aggregation and platelet and leucocytes adhesion in the microvasculature, modulates cytoskeletal function [reviewed in Ref. 52].

nNOS Regulation (involved) of iNOS in platelet associated with adhesions

2) Confidence 0.07 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.09 Pain Relevance 0

General Comments

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