INT249955

Context Info Confidence 0.02 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.33 Pain Relevance 0.06

extracellular space (Cpa1, Nos2) aging (Nos2) peroxisome (Nos2) intracellular (Nos2) cytoplasm (Nos2) cytosol (Nos2)

Anatomy Link Frequency platelet 1 Cpa1 (Mus musculus) Nos2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cva 3 64.80 Inflammation 4 62.96 narcan 1 5.00 cytokine 1 5.00 withdrawal 1 5.00 Morphine 1 5.00 Bioavailability 1 5.00 Inflammatory mediators 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Stress 2 79.72 Hemorrhage 3 64.80 INFLAMMATION 5 62.96 Injury 1 60.72 Hemorrhagic Shock 1 58.08 Adhesions 2 35.80 Hematological Disease 4 25.68 Thrombocytopenia 3 5.00 Body Weight 2 5.00 Aplasia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, CPA-induced upregulation of NOS isoforms of platelet, especially iNOS (elevated 10.7 times compared to control), could be contributed to overproduction of NO.

CPA Positive_regulation (upregulation) of iNOS in platelet

1) Confidence 0.02 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.33 Pain Relevance 0.06

General Comments

This test has worked.