INT250076

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.35

signal transduction (Grin2a) plasma membrane (Grin2a) locomotion (Grin2a)

Anatomy Link Frequency spike 2 Grin2a (Rattus norvegicus) Ltp (Mus musculus)

Pain Link Frequency Relevance Heat long-term potentiation 74 100.00 Action potential 3 98.24 Pyramidal cell 3 83.44 Hippocampus 10 81.28 antagonist 17 57.68 nMDA receptor 4 50.00 amygdala 8 5.00 imagery 6 5.00 isoflurane 3 5.00 Anterior cingulate cortex 1 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 47 55.84 Shock 1 23.24 Pain 1 5.00 Targeted Disruption 1 5.00 Anaerobic Bacterial Infections 1 5.00

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Anatomy

Negation

Speculation

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To test whether the involvement of NR2B-NMDARs is dependent on specific LTP induction paradigm, we first examined the role of NR2B- and NR2A-NMDARs in LTP induced by spike-timing protocol (also named EPSPs-APs protocol) (Figure 1A).

NR2A-NMDARs Spec (examined) Regulation (role) of Positive_regulation (induced) of LTP in spike associated with action potential and long-term potentiation

1) Confidence 0.10 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.06 Pain Relevance 0.35

General Comments

This test has worked.