INT250250

Context Info Confidence 0.37 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.10 Pain Relevance 0.39

plasma membrane (AQP4, SLC1A2) transmembrane transport (AQP4, SLC1A2) transport (AQP4) cytoplasm (AQP4)

Anatomy Link Frequency astrocyte 3 AQP4 (Homo sapiens) SLC1A2 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 54 98.94 Spinal cord 15 95.36 Central nervous system 21 81.40 Glutamate receptor 4 75.68 excitatory amino acid 2 66.04 Inflammatory response 1 60.64 Multiple sclerosis 8 23.68 Inflammation 7 5.00 Demyelination 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 3 99.98 Neuromyelitis Optica 87 96.70 INFLAMMATION 8 60.28 Autoimmune Disease 3 57.16 Demyelinating Disease 15 23.68 Toxicity 5 5.00 Neurodegenerative Disease 3 5.00 Pressure And Volume Under Development 2 5.00 Necrosis 1 5.00 Disease Progression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, we demonstrate that: (a) when active complement is present, binding of NMO-IgG to AQP4 in astrocyte membranes causes membrane lesioning; (b) in the absence of complement, NMO-IgG causes antigen-specific removal of AQP4 from astrocytic membranes with reduction of Na+-dependent glutamate transport and loss of surface EAAT2; (c) transgenic expression of AQP4 in nonastrocytic cells, and physiological up-regulation of AQP4 in differentiating astrocytes, induces surface EAAT2 expression; (d) AQP4 and EAAT2 exist in astrocytic membranes as a macromolecular complex; and (e) regions of AQP4 loss in NMO spinal cord lesions are deficient in EAAT2.

Gene_expression (expression) of AQP4 in astrocyte Positive_regulation (induces) of Gene_expression (expression) of EAAT2 in astrocyte associated with targeted disruption, neuromyelitis optica, glutamate and spinal cord

1) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 1.10 Pain Relevance 0.39

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