INT250276

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.40
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC1A2) transmembrane transport (SLC1A2)
Anatomy Link Frequency
vesicles 1
SLC1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 84 99.84 Very High Very High Very High
Glutamate 216 88.56 High High
Spinal cord 60 63.12 Quite High
addiction 4 33.88 Quite Low
Multiple sclerosis 32 5.00 Very Low Very Low Very Low
Inflammation 28 5.00 Very Low Very Low Very Low
Glutamate receptor 16 5.00 Very Low Very Low Very Low
excitatory amino acid 8 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 348 99.52 Very High Very High Very High
Targeted Disruption 12 6.80 Low Low
Demyelinating Disease 60 5.00 Very Low Very Low Very Low
INFLAMMATION 32 5.00 Very Low Very Low Very Low
Toxicity 20 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Autoimmune Disease 12 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The white color that resulted when the images were merged suggested partial colocalization of AQP4 and EAAT2 in early endosomes (Fig. 4 B).
Spec (partial) Localization (colocalization) of EAAT2
1) Confidence 0.61 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.74 Pain Relevance 0.06
Colocalization of AQP4 and EAAT2 in CNS tissue
Localization (Colocalization) of EAAT2 associated with central nervous system
2) Confidence 0.61 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.21 Pain Relevance 0.20
Higher magnification (Fig. 4 A) revealed apparent colocalization of EAAT2 and AQP4 in early endosomal vesicles to which we previously demonstrated AQP4 translocation after exposure to NMO serum (6).
Localization (colocalization) of EAAT2 in vesicles associated with neuromyelitis optica
3) Confidence 0.61 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.68 Pain Relevance 0.13
Exposure to NMO-IgG did not affect the distribution of EAAT1 or EAAT2 in AQP5-GFP cells (Fig. 4, C and E).
Localization (distribution) of EAAT2 associated with neuromyelitis optica
4) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.77 Pain Relevance 0.04

General Comments

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