INT250279

Context Info Confidence 0.46 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.69 Pain Relevance 0.13

transport (AQP4) plasma membrane (AQP4) transmembrane transport (AQP4) cytoplasm (AQP4)

Anatomy Link Frequency vesicles 2 AQP4 (Homo sapiens)

Pain Link Frequency Relevance Heat Glutamate 54 77.56 addiction 1 30.52 Central nervous system 21 5.00 Spinal cord 15 5.00 Multiple sclerosis 8 5.00 Inflammation 7 5.00 Glutamate receptor 4 5.00 excitatory amino acid 2 5.00 Demyelination 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Neuromyelitis Optica 87 99.24 Demyelinating Disease 15 5.00 INFLAMMATION 8 5.00 Toxicity 5 5.00 Targeted Disruption 3 5.00 Neurodegenerative Disease 3 5.00 Autoimmune Disease 3 5.00 Pressure And Volume Under Development 2 5.00 Necrosis 1 5.00 Disease Progression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Higher magnification (Fig. 4 A) revealed apparent colocalization of EAAT2 and AQP4 in early endosomal vesicles to which we previously demonstrated AQP4 translocation after exposure to NMO serum (6).

Positive_regulation (demonstrated) of Localization (translocation) of AQP4 in vesicles associated with neuromyelitis optica

1) Confidence 0.46 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571922 Disease Relevance 0.69 Pain Relevance 0.13

General Comments

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