INT250326

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.93 Pain Relevance 0.59

cytoplasm (Il12a, Rpsa) structural constituent of ribosome (Rpsa) ribosome (Rpsa) intracellular (Rpsa) cytosol (Rpsa) extracellular space (Il12a)

Anatomy Link Frequency Th1 cell 1 Il12a (Mus musculus) Rpsa (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 11 99.00 rheumatoid arthritis 13 97.92 Pain 1 89.84 Inflammation 4 84.80 chemokine 2 76.52 Arthritis 24 51.00 addiction 1 37.92 Demyelination 2 5.00 Inflammatory response 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 13 97.92 Pain 1 89.84 Pressure And Volume Under Development 3 88.88 INFLAMMATION 5 84.80 Disease 10 79.52 Autoimmune Disease 1 55.44 Arthritis 28 51.00 Necrosis 2 50.00 Cancer 2 50.00 Immunization 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

IL-23 is a heterodimeric protein composed of a p19 subunit and a p40 subunit, whereas IL-12, an important cytokine for Th1 cell differentiation, is formed when the p40 subunit dimerizes with p35 (8).

p35 Binding (dimerizes) of p40 in Th1 cell associated with cytokine

1) Confidence 0.09 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.93 Pain Relevance 0.59

General Comments

This test has worked.