INT250351

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.14
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Best1) plasma membrane (Best1)
Anatomy Link Frequency
neck 2
macrophage 2
eyes 2
Best1 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 34 99.24 Very High Very High Very High
Sciatic nerve 78 98.40 Very High Very High Very High
cytokine 30 89.28 High High
Inflammation 34 84.24 Quite High
Spinal cord 32 57.48 Quite High
imagery 5 54.16 Quite High
Central nervous system 4 51.36 Quite High
cva 7 5.00 Very Low Very Low Very Low
Neuritis 6 5.00 Very Low Very Low Very Low
Peripheral nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 64 100.00 Very High Very High Very High
Osteoporosis 21 99.98 Very High Very High Very High
Breast Cancer 39 99.30 Very High Very High Very High
Demyelinating Disease 44 99.24 Very High Very High Very High
Paralysis 68 98.36 Very High Very High Very High
Death 25 97.52 Very High Very High Very High
Osteoporotic Fractures 4 96.76 Very High Very High Very High
Disease 90 95.04 Very High Very High Very High
Chronic Inflammatory Demyelinating Polyradiculoneuropathy 16 89.72 High High
INFLAMMATION 34 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S2G), despite the increased expression of VMD2 and IL-10 in the eyes of these animals.
Positive_regulation (increased) of Gene_expression (expression) of VMD2 in eyes
1) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 0.53 Pain Relevance 0.19
In conclusion, VMD2-driven transgenic expression of IL-10 results in macrophage recruitment and FasL-mediated demyelination of the sciatic nerve, axonal death, and ultimately paralysis.
Positive_regulation (recruitment) of Gene_expression (expression) of VMD2-driven in macrophage associated with targeted disruption, demyelination, sciatic nerve, paralysis and death
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.50 Pain Relevance 0.41
VRAC was rescued by overexpressing bestrophin-1 mutants with altered biophysical properties and responsiveness to sulfhydryl reagents.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of bestrophin-1
3) Confidence 0.15 Published 2008 Journal The Journal of General Physiology Section Abstract Doc Link PMC2571971 Disease Relevance 0.08 Pain Relevance 0
In TROPOS, at three years in the SR group a 5.7% baseline percentage increment in BMD was observed at the femoral neck and 7.1% at the total hip (P = 0.001), compared with the placebo group.22
Positive_regulation (increment) of Gene_expression (group) of BMD in neck
4) Confidence 0.08 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971725 Disease Relevance 0.24 Pain Relevance 0
Breast cancer patients found to have osteopenia based on BMD results (t score between ?
Positive_regulation (based) of Gene_expression (results) of BMD associated with breast cancer and osteoporosis
5) Confidence 0.05 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2690973 Disease Relevance 0.79 Pain Relevance 0.05

General Comments

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