INT250743

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 20.97
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (CC2D1A) microtubule organizing center (CC2D1A) cytoplasm (CC2D1A)
signal transducer activity (CC2D1A) signal transduction (CC2D1A) nucleolus (CC2D1A)
Anatomy Link Frequency
blood 1
CC2D1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 77 100.00 Very High Very High Very High
Paracetamol 14 99.40 Very High Very High Very High
Inflammation 20 98.20 Very High Very High Very High
cINOD 46 89.16 High High
Inflammatory response 50 30.00 Quite Low
aspirin 9 19.04 Low Low
corticosteroid 7 16.04 Low Low
withdrawal 7 13.16 Low Low
ischemia 32 5.00 Very Low Very Low Very Low
agonist 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 2349 100.00 Very High Very High Very High
Hemolytic Uremic Syndrome 63 99.74 Very High Very High Very High
Pressure Volume 2 Under Development 16 98.80 Very High Very High Very High
INFLAMMATION 119 98.20 Very High Very High Very High
Necrosis 163 97.48 Very High Very High Very High
Hypoxia 207 93.28 High High
Chronic Renal Failure 185 92.56 High High
Critical Illness 54 92.40 High High
Frailty 7 91.80 High High
Death 22 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
diuretic therapy in AKI shortens hospital stay, decreases the need for dialysis therapy and decreases mortality rates: true or false‘renal-dose’ dopamine therapy has not been shown to be effective in adult patients: true or falseprevention of AKI is important on a global scale in lowering the number of deaths from AKI: true or falsePrognosis of AKI
Localization (important) of AKI associated with dopamine and injury
1) Confidence 0.51 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.78 Pain Relevance 0.08
Cisplatin, ifosfamide, acyclovir, amphotericin B, and acetaminophen are also nephrotoxic and may precipitate AKI.
Localization (precipitate) of AKI associated with paracetamol and injury
2) Confidence 0.47 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.02 Pain Relevance 0.16
In many instances, such as AKI occurring in hospitalized children, multiple factors are likely to be implicated in the etiology of AKI.


Localization (etiology) of AKI associated with injury
3) Confidence 0.44 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.02 Pain Relevance 0.09
HUS is a common cause of AKI in children and leads to substantial morbidity and mortality rates and long-term complications that may not become apparent until adulthood [58].
Localization (cause) of AKI associated with injury and hemolytic uremic syndrome
4) Confidence 0.44 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.96 Pain Relevance 0
the incidence of AKI is decreasing: true or falsegenetic factors may play a role in the susceptibility to AKI: true or falsehypoxic/ischemic AKI is a rare cause of AKI in children: true or falsenonsteroidal anti-inflammatory therapy is a risk factor for AKI in newborns: true or falseDiagnosis and etiology of AKI in children
Localization (cause) of AKI associated with inflammation and injury
5) Confidence 0.44 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.19 Pain Relevance 0.05
diuretic therapy in AKI shortens hospital stay, decreases the need for dialysis therapy and decreases mortality rates: true or false‘renal-dose’ dopamine therapy has not been shown to be effective in adult patients: true or falseprevention of AKI is important on a global scale in lowering the number of deaths from AKI: true or falsePrognosis of AKI
Localization (important) of AKI associated with dopamine and injury
6) Confidence 0.44 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.21 Pain Relevance 0.08
the incidence of AKI is decreasing: true or falsegenetic factors may play a role in the susceptibility to AKI: true or falsehypoxic/ischemic AKI is a rare cause of AKI in children: true or falsenonsteroidal anti-inflammatory therapy is a risk factor for AKI in newborns: true or falseDiagnosis and etiology of AKI in children
Localization (cause) of AKI associated with inflammation and injury
7) Confidence 0.44 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.20 Pain Relevance 0.05
Less prominent in the clinician's mind are dose adjustments for changes in hepatic clearance during AKI.
Localization (clearance) of AKI associated with injury
8) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.88 Pain Relevance 0
To consider AKI as a single homogenous entity is an oversimplification because there are many etiologies of AKI and each of their clinical presentations are distinct.
Localization (etiologies) of AKI associated with injury
9) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.60 Pain Relevance 0
We conducted a single-center study with 662 ICU patients to compare the new recently released definitions/classifications for AKI – the RIFLE system and the AKIN system.
Localization (released) of AKI associated with injury
10) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2575599 Disease Relevance 0.44 Pain Relevance 0
Theoretically, the presence of AKI might even increase the potential role of antioxidants.
Localization (presence) of AKI associated with injury
11) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2575562 Disease Relevance 0.98 Pain Relevance 0
Demographic characteristics and specific information, such as cause of AKI, co-morbidities presented by each patient, use of medications, time to develop AKI after ICU admission, length of hospital stay, need for surgery, mechanism of injury, time to beginning dialysis and the cause of death, were evaluated.
Localization (cause) of AKI associated with injury and death
12) Confidence 0.06 Published 2010 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC3021827 Disease Relevance 1.54 Pain Relevance 0
AKI was defined according to the RIFLE criteria, based on creatinine, and patients were investigated for the presence of AKI during the hospital stay.[1] Hypotension was defined as mean arterial blood pressure (MAP) of <60 mmHg and therapy with vasoactive drugs was initiated when MAP remained lower than 60 mmHg.
Spec (investigated) Localization (presence) of AKI in blood associated with pressure volume 2 under development and injury
13) Confidence 0.05 Published 2010 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC3021827 Disease Relevance 1.15 Pain Relevance 0

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