INT250796

Context Info Confidence 0.14 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.00 Pain Relevance 0.03

nucleoplasm (Parp1) nuclear envelope (Parp1) intracellular (Tlr4) protein complex (Parp1) cytoplasm (Tlr4) signal transduction (Tlr4)

Tlr4 (Mus musculus) Parp1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 23 54.96 ischemia 1 49.44 cytokine 10 5.00 Inflammatory mediators 3 5.00 iatrogenic 1 5.00 anesthesia 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Injury 6 97.16 Lung Injury 102 82.84 Heart Rate Under Development 1 60.76 Adult Respiratory Distress Syndrome 25 58.00 INFLAMMATION 25 54.96 Hyperoxia 2 50.72 Cv Unclassified Under Development 1 49.44 Burns 1 47.36 Pancreatitis 1 46.28 Sepsis 1 45.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It would be difficult to determine whether PARP is activated by LPS, injurious MV setting, or both and whether the PARP inhibitor exerts its effect by inhibition of PARP from LPS, injurious MV setting, or both.

LPS Spec (whether) Positive_regulation (activated) of PARP

1) Confidence 0.14 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.00 Pain Relevance 0.03

General Comments

This test has worked.