INT250852

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fgf8, Ecm1) enzyme binding (Ecm1) signal transducer activity (Ecm1)
signal transduction (Ecm1) extracellular region (Ecm1) proteinaceous extracellular matrix (Ecm1)
Fgf8 (Rattus norvegicus)
Ecm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 38 90.16 High High
Inflammation 7 81.28 Quite High
Pain 5 65.52 Quite High
metalloproteinase 8 49.28 Quite Low
Analgesic 2 41.12 Quite Low
Arthritis 15 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 39 90.16 High High
INFLAMMATION 8 81.28 Quite High
Disease Progression 1 79.80 Quite High
Pain 5 65.52 Quite High
Injury 5 7.44 Low Low
Arthritis 15 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 causes both matrix degradation and downregulation of proteoglycan synthesis [37], but further studies are required to clarify whether FGF8 also downregulates ECM synthesis.
FGF8 Spec (whether) Negative_regulation (downregulates) of Gene_expression (synthesis) of ECM
1) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 1.10 Pain Relevance 0.54

General Comments

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