INT250934

Context Info Confidence 0.39 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.62 Pain Relevance 1.34

extracellular region (BDNF, NGF) endosome (NGF) signal transduction (NGF) extracellular space (NGF) cytoplasmic membrane-bounded vesicle (BDNF)

BDNF (Homo sapiens) NGF (Homo sapiens)

Pain Link Frequency Relevance Heat Nerve growth factor 122 100.00 substance P 26 100.00 Neurotransmitter 1 93.28 nociceptor 1 80.56 Lasting pain 2 76.32 Inflammation 5 74.16 cytokine 36 73.28 backache 7 65.00 Pain 31 60.00 neurotrophin 3 3 59.68

Disease Link Frequency Relevance Heat Nociception 17 90.08 Pain 29 75.44 INFLAMMATION 5 74.16 Low Back Pain 11 65.00 Intervertebral Disk Degeneration 10 62.08 Disease 21 5.00 Osteoarthritis 6 5.00 Cancer 4 5.00 Inflammatory Pain 4 5.00 Necrosis 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Quantitative real-time PCR was carried out using the predesigned FAM MGB combined primer and the probe sets termed assays on demand for NGF, BDNF and substance P from Applied Biosystems (Warrington, UK): NGF, Hs00171458_m1; BDNF, Hs00542425_s1; substance P, Hs00243225_m1.

BDNF Binding (demand) of NGF associated with nerve growth factor and substance p

1) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0 Pain Relevance 0.34

Quantitative real-time PCR was carried out using the predesigned FAM MGB combined primer and the probe sets termed assays on demand for NGF, BDNF and substance P from Applied Biosystems (Warrington, UK): NGF, Hs00171458_m1; BDNF, Hs00542425_s1; substance P, Hs00243225_m1.

BDNF Binding (demand) of NGF associated with nerve growth factor and substance p

2) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0 Pain Relevance 0.34

In addition to NGF, BDNF has recognized neuroprotective effects [21].

BDNF Binding (recognized) of NGF associated with nerve growth factor

3) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.62 Pain Relevance 0.67

General Comments

This test has worked.