INT251088

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (G0s2)
Anatomy Link Frequency
HDF 1
G0s2 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 11 99.94 Very High Very High Very High
psoriasis 2 95.20 Very High Very High Very High
pain pelvic 1 89.60 High High
endometriosis 1 88.88 High High
Inflammatory mediators 1 32.84 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 11 99.94 Very High Very High Very High
Autoimmune Disease 16 99.70 Very High Very High Very High
Disease 9 96.22 Very High Very High Very High
Psoriasis 2 95.20 Very High Very High Very High
Aging 2 94.02 High High
Reprotox - General 3 2 89.92 High High
Endometriosis (extended) 1 88.88 High High
Vasculitis 88 63.32 Quite High
Panniculitis 3 52.00 Quite High
Systemic Lupus Erythematosus 12 46.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
G0S2 was first identified as one of the G0/G1 switch (G0S) genes that are differentially expressed in lymphocytes during their lectin-induced switch from the G0 to the G1 phases of the cell cycle.20 G0S2 is one of the genes that is upregulated during normal implantation but its expression is significantly lower in women with endometriosis that is associated with pelvic pain and infertility with implantation failure.21 In a replicative senescence model employing human dermal fibroblasts (HDF), G0S2 expression was upregulated in old HDF cells, which suggests that it participates in senescence.22 Microarray and qRT–PCR analyses of PBMCs from psoriasis patients suffering from severe generalized disease also revealed the upregulation of G0S2.13 Moreover, we showed previously that G0S2 mRNA levels are markedly increased in the PBMCs from patients with the autoimmune diseases SLE4 and RA.5 G0S2 is a putative target gene of peroxisome-proliferator-activated receptor (PPAR) alpha, which belongs to a group of transcription factors that are involved in numerous processes, including lipid metabolism and adipogenesis.
Regulation (target) of G0S2 in HDF associated with psoriasis, autoimmune disease, aging, rheumatoid arthritis, disease, endometriosis, reprotox - general 3 and pain pelvic
1) Confidence 0.27 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.02 Pain Relevance 0.23

General Comments

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