INT251153

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlg2, Grin2a) transport (Grin2a) locomotion (Grin2a)
cytoplasm (Dlg2)
Anatomy Link Frequency
forebrain 3
dorsal horn 1
Dlg2 (Mus musculus)
Grin2a (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 24 99.48 Very High Very High Very High
Dorsal horn neuron 2 98.40 Very High Very High Very High
Hippocampus 6 84.48 Quite High
Central nervous system 22 72.48 Quite High
Morphine 154 64.44 Quite High
tolerance 50 50.00 Quite Low
Physical dependence 30 50.00 Quite Low
withdrawal 46 48.52 Quite Low
narcan 12 47.56 Quite Low
Spinal cord 16 27.92 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 102 98.64 Very High Very High Very High
Drug Dependence 30 50.00 Quite Low
Substance Withdrawal Syndrome 8 48.88 Quite Low
Pain 36 24.16 Low Low
INFLAMMATION 4 7.84 Low Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Pathologic Processes 4 5.00 Very Low Very Low Very Low
Cerebellar Diseases 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data suggest that PSD-93 is required for synaptic expression and localization of NR2A and NR2B in dorsal horn and forebrain cortex.
PSD-93 Positive_regulation (required) of Gene_expression (expression) of NR2A in forebrain associated with dorsal horn
1) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.30 Pain Relevance 0.46
The data suggest that PSD-93 is required for synaptic expression and localization of NR2A and NR2B in dorsal horn and forebrain cortex.
PSD-93 Positive_regulation (required) of in dorsal horn Gene_expression (expression) of NR2A in forebrain associated with dorsal horn
2) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.30 Pain Relevance 0.46

General Comments

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