INT251159

Context Info Confidence 0.16 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.87

cytosol (Clu, Trpv1) mitochondrion (Clu) endoplasmic reticulum (Clu) lipid metabolic process (Trpv1) response to stress (Clu) cytoplasm (Clu)

Clu (Rattus norvegicus) Trpv1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat qutenza 44 99.68 Kinase C 21 68.40 dorsal root ganglion 28 49.68 bradykinin 2 42.72 Serotonin 1 39.36 nociceptor 1 34.72 Inflammation 4 32.24 Hyperalgesia 2 31.20 imagery 9 5.00 TRP channel 5 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 28 49.68 INFLAMMATION 4 32.24 Hyperalgesia 3 31.20 Nociception 3 5.00 Pain 1 5.00 Aids-related Complex 1 5.00 Rupture 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results consistently support the hypothesis that DAG and its analogs activate TRPV1 directly by binding at the capsaicin-binding site.

DAG Binding (binding) of Positive_regulation (activate) of TRPV1 associated with qutenza

1) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576176 Disease Relevance 0 Pain Relevance 0.87

General Comments

This test has worked.