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Context Info
Confidence 0.35
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.86
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGDS) transport (PTGDS) extracellular space (PTGDS)
extracellular region (PTGDS) Golgi apparatus (PTGDS) nucleus (PTGDS)
Anatomy Link Frequency
platelet 2
Th2 cells 1
PTGDS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
aspirin 10 99.70 Very High Very High Very High
Paracetamol 13 99.46 Very High Very High Very High
Inflammation 70 98.56 Very High Very High Very High
cINOD 9 95.72 Very High Very High Very High
nud 58 94.48 High High
Inflammatory response 3 88.24 High High
Osteoarthritis 158 83.24 Quite High
Serotonin 1 77.76 Quite High
agonist 1 69.76 Quite High
Disease Link Frequency Relevance Heat
Syndrome 20 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 42 99.70 Very High Very High Very High
INFLAMMATION 76 98.56 Very High Very High Very High
Dyspepsia 58 94.48 High High
Volume Depletion And Dehydration 2 94.28 High High
Disease 24 93.08 High High
Stress 19 90.96 High High
Crystal Associated Disease 4 90.16 High High
Rhinitis 2 89.68 High High
Osteoarthritis 167 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGD2 exerts its effects principally by binding and activating two plasma membrane receptors, the D prostanoid receptor (DP) 1 [15] and chemoattractant-receptor-like molecule expressed on Th2 cells (CRTH2), also known as DP2 [16].
PGD2 Binding (binding) of in Th2 cells
1) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 1.22 Pain Relevance 0.37
It can be assumed that inhibition of this receptor does not reduce the production of prostaglandins, but inhibits the vasodilatation following the formation of PGD2.
PGD2 Binding (formation) of associated with increased venous pressure under development
2) Confidence 0.33 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.73 Pain Relevance 0.21
Interestingly, the promoter region of the human L-PGDS contains binding sites for NF-?
L-PGDS Binding (binding) of
3) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0 Pain Relevance 0
On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.
prostaglandin D2 Binding (interaction) of associated with antagonist
4) Confidence 0.29 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16418339 Disease Relevance 0.28 Pain Relevance 0.17
In washed platelet suspensions labeled with 3H-arachidonate, both APAP and aspirin inhibited the formation of labeled PGD2 and PGE2, as well as TxB2.
PGD2 Binding (formation) of in platelet associated with aspirin and paracetamol
5) Confidence 0.27 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 0.96
It can bind to both PGH2 and PGD2 [15].
PGD2 Binding (bind) of
6) Confidence 0.26 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0
Taken altogether, our data suggest that COX-2-derived PGD2 and/or its metabolite 15-deoxy-?
PGD2 Binding (suggest) of
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.65 Pain Relevance 0.27
The aim of the present study was to determine the mechanism by which aspirin acutely increases the activity of NO synthase type 3 (NOS-3), the predominant NOS isoform expressed by platelets, and specifically whether this occurs through an increase in its acetylation.
NO synthase type 3 Binding (activity) of in platelets associated with aspirin
8) Confidence 0.03 Published 2009 Journal Cardiovasc. Res. Section Abstract Doc Link 19377066 Disease Relevance 0.10 Pain Relevance 0.23
We also found significant inverse association between the same genotype with PDS among H. pylori positive subjects (ins/ins vs del carrier; OR = 0.22, 95% CI = 0.07–0.70, p = 0.01).
PDS Binding (association) of associated with syndrome
9) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.89 Pain Relevance 0.33

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