INT25119

Context Info Confidence 0.35 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 3.86 Pain Relevance 2.54

isomerase activity (PTGDS) transport (PTGDS) extracellular space (PTGDS) extracellular region (PTGDS) Golgi apparatus (PTGDS) nucleus (PTGDS)

Anatomy Link Frequency platelet 2 Th2 cells 1 PTGDS (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 7 100.00 aspirin 10 99.70 Paracetamol 13 99.46 Inflammation 70 98.56 cINOD 9 95.72 nud 58 94.48 Inflammatory response 3 88.24 Osteoarthritis 158 83.24 Serotonin 1 77.76 agonist 1 69.76

Disease Link Frequency Relevance Heat Syndrome 20 100.00 Increased Venous Pressure Under Development 42 99.70 INFLAMMATION 76 98.56 Dyspepsia 58 94.48 Volume Depletion And Dehydration 2 94.28 Disease 24 93.08 Stress 19 90.96 Crystal Associated Disease 4 90.16 Rhinitis 2 89.68 Osteoarthritis 167 83.24

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

PGD2 exerts its effects principally by binding and activating two plasma membrane receptors, the D prostanoid receptor (DP) 1 [15] and chemoattractant-receptor-like molecule expressed on Th2 cells (CRTH2), also known as DP2 [16].

PGD2 Binding (binding) of in Th2 cells

1) Confidence 0.35 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 1.22 Pain Relevance 0.37

It can be assumed that inhibition of this receptor does not reduce the production of prostaglandins, but inhibits the vasodilatation following the formation of PGD2.

PGD2 Binding (formation) of associated with increased venous pressure under development

2) Confidence 0.33 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.73 Pain Relevance 0.21

Interestingly, the promoter region of the human L-PGDS contains binding sites for NF-?

L-PGDS Binding (binding) of

3) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0 Pain Relevance 0

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.

prostaglandin D2 Binding (interaction) of associated with antagonist

4) Confidence 0.29 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16418339 Disease Relevance 0.28 Pain Relevance 0.17

In washed platelet suspensions labeled with 3H-arachidonate, both APAP and aspirin inhibited the formation of labeled PGD2 and PGE2, as well as TxB2.

PGD2 Binding (formation) of in platelet associated with aspirin and paracetamol

5) Confidence 0.27 Published 1989 Journal Thromb. Res. Section Abstract Doc Link 2499947 Disease Relevance 0 Pain Relevance 0.96

It can bind to both PGH2 and PGD2 [15].

PGD2 Binding (bind) of

6) Confidence 0.26 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0

Taken altogether, our data suggest that COX-2-derived PGD2 and/or its metabolite 15-deoxy-?

PGD2 Binding (suggest) of

7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.65 Pain Relevance 0.27

The aim of the present study was to determine the mechanism by which aspirin acutely increases the activity of NO synthase type 3 (NOS-3), the predominant NOS isoform expressed by platelets, and specifically whether this occurs through an increase in its acetylation.

NO synthase type 3 Binding (activity) of in platelets associated with aspirin

8) Confidence 0.03 Published 2009 Journal Cardiovasc. Res. Section Abstract Doc Link 19377066 Disease Relevance 0.10 Pain Relevance 0.23

We also found significant inverse association between the same genotype with PDS among H. pylori positive subjects (ins/ins vs del carrier; OR = 0.22, 95% CI = 0.07–0.70, p = 0.01).

PDS Binding (association) of associated with syndrome

9) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.89 Pain Relevance 0.33

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