INT251326

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.87
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Limk1) nucleus (Limk1) kinase activity (Limk1)
cytoplasm (Limk1)
Anatomy Link Frequency
eyes 1
Limk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 165 97.68 Very High Very High Very High
fibrosis 60 96.52 Very High Very High Very High
Inflammatory response 45 89.96 High High
ketamine 5 36.04 Quite Low
anesthesia 5 34.28 Quite Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 45 98.04 Very High Very High Very High
Ocular & Orbital Inflammation 65 97.68 Very High Very High Very High
Fibrosis 70 96.52 Very High Very High Very High
INFLAMMATION 145 89.60 High High
Injury 70 85.16 High High
Dislocations 5 65.52 Quite High
Keloid Scars 40 37.76 Quite Low
Glaucoma 20 5.00 Very Low Very Low Very Low
Stress 15 5.00 Very Low Very Low Very Low
Cataract 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LIMK1 siRNA inhibits fibronectin assembly and fibronectin secretion
Gene_expression (assembly) of LIMK1
1) Confidence 0.67 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.30 Pain Relevance 0.12
Also, LIMK2, a member of the LIMK family, can be indirectly activated by TGF-?
Gene_expression (family) of LIMK
2) Confidence 0.67 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.37 Pain Relevance 0
The links between LIMK1 and transcriptional pathways regulated by TGF-?
Gene_expression (pathways) of LIMK1
3) Confidence 0.67 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.29 Pain Relevance 0
The fibronectin deposition was significantly diminished in cultures 48 (data not shown) and 72 h (Figure 1D,E) after transfection with both 50 nM and 100 nM LIMK1 siRNA.
Gene_expression (transfection) of LIMK1
4) Confidence 0.67 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0 Pain Relevance 0
A direct application of siRNA into eyes to downregulate LIMK1 expression may provide a novel therapy for suppression and prevention of ocular inflammation and fibrosis.



Gene_expression (expression) of LIMK1 in eyes associated with fibrosis, inflammation and ocular & orbital inflammation
5) Confidence 0.60 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2576479 Disease Relevance 0.90 Pain Relevance 0.35

General Comments

This test has worked.

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