INT251450

From wiki-pain
Revision as of 02:29, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.18
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnc1) molecular_function (Dpp6) cellular_component (Dpp6)
transmembrane transport (Kcnc1)
Anatomy Link Frequency
neurons 2
brain 2
neuronal 1
projection neurons 1
granule cells 1
Dpp6 (Mus musculus)
Kcnc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 72 92.16 High High
Hippocampus 45 54.88 Quite High
addiction 9 45.08 Quite Low
Pain 9 38.96 Quite Low
repetitive firing 9 23.72 Low Low
Thalamus 9 16.32 Low Low
Substantia nigra 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 36 73.12 Quite High
Disease 27 56.20 Quite High
Pain 9 38.96 Quite Low
Epilepsy 9 38.60 Quite Low
Infection 9 23.76 Low Low
Sprains And Strains 9 5.00 Very Low Very Low Very Low
Adhesions 9 5.00 Very Low Very Low Very Low
Motor Neuron Diseases 9 5.00 Very Low Very Low Very Low
Autism 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In heterologous cells, DPP6 and DPP10 can interact with all three Kv4 proteins, however, in-situ hybridization studies showed that the two DPPL genes tended to be expressed in different neurons, with neuronal populations expressing mainly Kv4.2 containing DPP6 mRNAs, while DPP10 was the predominant DPPL in cells expressing Kv4.3, although exceptions to this pattern were noted (Nadal et al., 2006; Zagha et al., 2005).
DPP6 Binding (interact) of Kv4 in neuronal
1) Confidence 0.37 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0.12 Pain Relevance 0.03
It is also possible that there is DPP6 protein that is not associated with Kv4.2 in the very distal apical dendrites of CA1 neurons, or that the two antibodies have different access to the subcellular compartments where channel complexes are located in distal dendrites.
DPP6 protein Binding (associated) of Kv4 in neurons
2) Confidence 0.37 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0
We found that the cellular and subcellular pattern of expression of DPP6 closely matches that of Kv4.2, supporting the hypothesis that DPP6 is associated with Kv4 channels in the brain.
DPP6 Binding (associated) of Kv4 in brain
3) Confidence 0.29 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0
In the caudate/putamen, immunoreactivity for Kv4.2 and DPP6 was concentrated in the neuropil, as previously reported for Kv4.2 in rat (Rhodes et al., 2004; Figure 3), where the staining is likely to be associated with the somata and dendrites of striatal projection neurons (Rhodes et al., 2004).
DPP6 Binding (immunoreactivity) of Kv4 in projection neurons associated with pyramidal cell
4) Confidence 0.28 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0.07
In the dentate gyrus, immunoreactivity for both Kv4.2 and DPP6 was concentrated in the molecular layer (Figures 5B,D), where the dendrites of dentate granule cells are located (Figure 5A).
DPP6 Binding (immunoreactivity) of Kv4 in granule cells
5) Confidence 0.28 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0.10
First, the finding that DPP6 and DPP10 associate and modulate Kv4 channels is surprising, since all other known DPPs are enzymes and there is no precedent for these proteins functioning as modulators of other membrane proteins.
DPP6 Binding (associate) of Kv4
6) Confidence 0.25 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0.06 Pain Relevance 0
We found that the cellular and subcellular pattern of expression of DPP6 closely matches that of Kv4.2, supporting the hypothesis that DPP6 is associated with Kv4 channels in the brain.
DPP6 Binding (associated) of Kv4 in brain
7) Confidence 0.24 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0
Second, the interaction between DPP6 and Kv4 subunits appears to be relatively weak, and in the experiments of Nadal et al. (2003) cross-linking of channel complexes was necessary to stabilize their association during solubilization.
DPP6 Binding (interaction) of Kv4
8) Confidence 0.24 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0
If DPP6 proteins are associated with Kv4 channels in neurons one would predict that the two types of protein would be expressed in the same neurons and in the same neuronal compartments.
DPP6 Binding (associated) of Kv4 in neurons
9) Confidence 0.24 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox