INT251453

Context Info Confidence 0.20 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.18 Pain Relevance 0.18

transport (Kcnc1) transmembrane transport (Kcnc1)

Anatomy Link Frequency neuronal 1 neurons 1 Kcnc1 (Mus musculus) Dpp10 (Mus musculus)

Pain Link Frequency Relevance Heat Substantia nigra 3 71.60 Pyramidal cell 24 63.56 Hippocampus 15 60.40 addiction 3 44.72 Pain 3 38.60 repetitive firing 3 23.36 Thalamus 3 16.32

Disease Link Frequency Relevance Heat Targeted Disruption 12 72.76 Disease 9 55.84 Pain 3 38.60 Epilepsy 3 38.24 Sprains And Strains 3 5.00 Adhesions 3 5.00 Motor Neuron Diseases 3 5.00 Autism 3 5.00 Infection 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In heterologous cells, DPP6 and DPP10 can interact with all three Kv4 proteins, however, in-situ hybridization studies showed that the two DPPL genes tended to be expressed in different neurons, with neuronal populations expressing mainly Kv4.2 containing DPP6 mRNAs, while DPP10 was the predominant DPPL in cells expressing Kv4.3, although exceptions to this pattern were noted (Nadal et al., 2006; Zagha et al., 2005).

Kv4 Binding (interact) of DPP10 in neuronal

1) Confidence 0.20 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0.12 Pain Relevance 0.03

As discussed earlier, the analysis of mRNA distribution suggests that instead, the Kv4 channels in these neurons are mainly associated with DPP10 (Zagha et al., 2005).

Kv4 Binding (associated) of DPP10 in neurons

2) Confidence 0.17 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0.15

First, the finding that DPP6 and DPP10 associate and modulate Kv4 channels is surprising, since all other known DPPs are enzymes and there is no precedent for these proteins functioning as modulators of other membrane proteins.

Kv4 Binding (associate) of DPP10

3) Confidence 0.14 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0.06 Pain Relevance 0

General Comments

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