INT25146

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Context Info
Confidence 0.43
First Reported 1987
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.91
Pain Relevance 4.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
muscle 2
globus pallidus 2
striatum 2
PGE2 2
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 194 100.00 Very High Very High Very High
narcan 134 100.00 Very High Very High Very High
Glutamate 15 100.00 Very High Very High Very High
Hyperalgesia 3 99.36 Very High Very High Very High
Morphine 152 99.20 Very High Very High Very High
antagonist 11 99.20 Very High Very High Very High
withdrawal 8 91.72 High High
Opioid 84 90.48 High High
nociceptor 1 90.08 High High
Enkephalin 3 89.52 High High
Disease Link Frequency Relevance Heat
Catalepsy 6 100.00 Very High Very High Very High
Hyperalgesia 3 99.36 Very High Very High Very High
Vibrio Infection 1 97.88 Very High Very High Very High
Injury 3 70.64 Quite High
Opiate Addiction 8 5.00 Very Low Very Low Very Low
Drug Dependence 4 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Bordatella Infection 2 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in glutamine synthetase activity in wounded muscle was prevented by adrenalectomy and restored by replacement doses of corticosterone in wounded adrenalectomized animals.
Negative_regulation (prevented) of Positive_regulation (increase) of glutamine synthetase in muscle
1) Confidence 0.43 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2880509 Disease Relevance 0.07 Pain Relevance 0.17
Although without effect alone, guanosine-5'-[gamma-thio]triphosphate (GTP gamma S) and cholera toxin--which activate Gs--both increased, while guanosine-5'-[beta-thio] diphosphate (GDP beta S)--which prevents the activation of Gs--decreased the hyperalgesia induced by PGE2.
Negative_regulation (prevents) of Positive_regulation (activation) of Gs in PGE2 associated with hyperalgesia and vibrio infection
2) Confidence 0.42 Published 1989 Journal Brain Res. Section Abstract Doc Link 2502301 Disease Relevance 0.36 Pain Relevance 0.44
When co-administered with haloperidol (seven days, 1 mg/kg s.c.), the muscarinic antagonist scopolamine (1 mg/kg, s.c.) completely blocked both haloperidol-induced catalepsy and increases in glutamate decarboxylase messenger RNA levels in the globus pallidus.
Negative_regulation (blocked) of Positive_regulation (increases) of glutamate decarboxylase in globus pallidus associated with glutamate, catalepsy and antagonist
3) Confidence 0.24 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637876 Disease Relevance 0.48 Pain Relevance 0.50
Treatment with L-DOPA (200 mg/kg/24 h) for eight weeks reduced but did not abolish the 6-hydroxydopamine lesion-induced elevation of preproenkephalin messenger RNA and slightly reduced the elevation of glutamate decarboxylase (M(r) 67,000) messenger RNA in denervated striatum relative to intact side and control groups.
Neg (not) Negative_regulation (reduced) of Positive_regulation (elevation) of glutamate decarboxylase in striatum associated with glutamate
4) Confidence 0.15 Published 1995 Journal Neuroscience Section Abstract Doc Link 7637869 Disease Relevance 0 Pain Relevance 0.30
Specifically, FLNA peptide fragments containing the NLX binding site blocked the protective effect of NLX on both the MOR–Gs coupling and downstream cAMP accumulation induced by chronic morphine (twice daily 1-hr exposures for 7 days), presumably by interfering with NLX's binding to FLNA in the tissues.
Negative_regulation (blocked) of Positive_regulation (accumulation) of Gs associated with mu opioid receptor, narcan and morphine
5) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.38
Similar to the blockade by a 100 pM concentration of the active isomer of NLX seen in Fig. 2, 100 pM (+)NLX blocked the Gs coupling induced by 15 min of 100 µM morphine (Fig. 3).


Negative_regulation (blocked) of Positive_regulation (induced) of Gs associated with narcan and morphine
6) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 1.75

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