INT25162

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.51
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ACPP) plasma membrane (ACPP) intracellular (ACPP)
Anatomy Link Frequency
granulocyte 1
macrophage 1
plasma 1
ACPP (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 5 98.08 Very High Very High Very High
Pain 5 82.68 Quite High
Inflammation 1 79.52 Quite High
backache 1 76.84 Quite High
imagery 5 72.88 Quite High
antagonist 1 60.84 Quite High
nud 5 58.88 Quite High
abdominal pain 3 54.60 Quite High
tolerance 2 39.68 Quite Low
Disease Link Frequency Relevance Heat
Prostate Cancer 40 99.90 Very High Very High Very High
Cancer 20 99.82 Very High Very High Very High
Carcinoma 2 98.28 Very High Very High Very High
Chronic Myeloid Leukemia 1 95.76 Very High Very High Very High
Metastasis 5 92.04 High High
Osteoporosis 2 91.60 High High
Diuresis 1 90.48 High High
Disease 7 88.88 High High
Pain 5 82.68 Quite High
Pressure And Volume Under Development 1 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor markers resulted negative except prostate specific antigen (PSA: 500 mgr/ml) and prostatic acid phosphatase (PAP: 208 U/l); prostate biopsy showed an undifferentiated carcinoma.
Neg (except) Positive_regulation (resulted) of prostatic acid phosphatase associated with cancer and carcinoma
1) Confidence 0.41 Published 2000 Journal Clin Ter Section Abstract Doc Link 11141722 Disease Relevance 1.10 Pain Relevance 0.08
Increased prostate-type acid phosphatase activity in serum and typical bone lesions simulating the presence of prostatic carcinoma.
Positive_regulation (Increased) of prostate-type acid phosphatase associated with prostate cancer
2) Confidence 0.39 Published 1984 Journal Clin. Chem. Section Title Doc Link 6585277 Disease Relevance 0.44 Pain Relevance 0.08
Thirteen patients were treated with two infusions, 1 month apart, of autologous dendritic cells (APC8015) preexposed ex vivo to PA2024, a fusion protein consisting of human granulocyte/macrophage-colony stimulating factor (GM-CSF) and human prostatic acid phosphatase (PAP).
Positive_regulation (consisting) of PAP in macrophage
3) Confidence 0.36 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10873066 Disease Relevance 0.61 Pain Relevance 0.07
Thirty-six men with disseminated prostatic cancer and elevated plasma levels of prostatic acid phosphatase were randomly assigned to two groups.
Positive_regulation (elevated) of prostatic acid phosphatase in plasma associated with prostate cancer
4) Confidence 0.12 Published 1989 Journal N. Engl. J. Med. Section Abstract Doc Link 2503723 Disease Relevance 0.57 Pain Relevance 0.07
Thirteen patients were treated with two infusions, 1 month apart, of autologous dendritic cells (APC8015) preexposed ex vivo to PA2024, a fusion protein consisting of human granulocyte/macrophage-colony stimulating factor (GM-CSF) and human prostatic acid phosphatase (PAP).
Positive_regulation (consisting) of PAP in granulocyte
5) Confidence 0.12 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10873066 Disease Relevance 0.61 Pain Relevance 0.07
Thus, one would expect regulators of Her2 activation, for example the different forms of the 100 kDa glycoprotein Prostatic Acid Phosphatase (PAcP), could be important factors in androgen dependence and tumor grade [21]–[26].
Positive_regulation (activation) of 100 kDa glycoprotein Prostatic Acid Phosphatase associated with addiction and cancer
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.47 Pain Relevance 0.08
There was an increase in alkaline phosphotase to 270 IU/L (27-120), tumor marker CA19-9 was 49.6 U/mL (0-35) and alpha fetoprotein was elevated to a level of 7.3 IU/mL (< 5.5).
Positive_regulation (increase) of phosphotase associated with cancer
7) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2833155 Disease Relevance 0.71 Pain Relevance 0.16

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