INT25175

Context Info Confidence 0.55 First Reported 1989 Last Reported 1994 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.40 Pain Relevance 0.52

nuclear chromosome (Msh2) ATPase activity (Msh2) nucleus (Msh2) enzyme binding (Msh2) cell cycle (Msh2) DNA binding (Msh2)

Msh2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 3 99.64 Morphine 3 98.68 opioid receptor 1 76.24 antagonist 1 75.60 opiate 1 71.64 anesthesia 1 25.00

Disease Link Frequency Relevance Heat Appetite Loss 2 99.40 Hypotension 2 93.60 Heart Rate Under Development 1 53.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Infusion of gamma 2-MSH produce a conditioned taste aversion in morphine-dependent rats.

Gene_expression (produce) of 2-MSH associated with appetite loss, narcan and morphine

1) Confidence 0.55 Published 1989 Journal Psychopharmacology (Berl.) Section Title Doc Link 2506600 Disease Relevance 0.18 Pain Relevance 0.52

Therefore, we conclude that in addition to a pressor and tachycardic response gamma 2-MSH can elicit an opposite effect by interaction with structures within a discrete region in the NTS, the pars commissuralis.

Gene_expression (pressor) of 2-MSH

2) Confidence 0.43 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8139700 Disease Relevance 0.22 Pain Relevance 0

General Comments

This test has worked.