INT25176

Context Info Confidence 0.37 First Reported 1987 Last Reported 1994 Negated 1 Speculated 1 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 0.48 Pain Relevance 0.68

nuclear chromosome (Msh2) ATPase activity (Msh2) nucleus (Msh2) enzyme binding (Msh2) cell cycle (Msh2) DNA binding (Msh2)

Anatomy Link Frequency blood 2 Msh2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 2 100.00 Intracerebroventricular 2 99.00 Morphine 3 81.28 narcan 4 77.04 antagonist 2 72.24 Opioid 1 70.48 opioid receptor 1 67.36 opiate 1 58.16 Central nervous system 1 46.68 cva 1 25.00

Disease Link Frequency Relevance Heat Pressure Volume 2 Under Development 1 97.20 Hypotension 2 95.44 Appetite Loss 2 75.12 Heart Rate Under Development 1 63.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A two flavour, unbiased, taste preference conditioning procedure was used to test for possible motivating effects of gamma 2-MSH.

Spec (possible) Regulation (effects) of 2-MSH

1) Confidence 0.37 Published 1989 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2506600 Disease Relevance 0.15 Pain Relevance 0.34

Effect of ACTH-(4-10) and gamma 2-MSH on blood pressure after intracerebroventricular and intracisternal administration.

Regulation (Effect) of gamma 2-MSH in blood associated with anesthesia and intracerebroventricular

2) Confidence 0.35 Published 1993 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 7687715 Disease Relevance 0 Pain Relevance 0.20

The responses were maximal after 3-4 min and lasted for about 15 min. gamma 2-MSH had no effect when injected into the AP.

Neg (no) Regulation (effect) of 2-MSH

3) Confidence 0.29 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8139700 Disease Relevance 0.23 Pain Relevance 0

The effect of intracerebroventricularly (i.c.v.) administered alpha-melanocyte-stimulating hormone (MSH) and gamma 2-MSH on hypothalamic blood flow autoregulation was studied in anesthetized rats at different levels of standardized arterial hypotension.

Regulation (autoregulation) of 2-MSH in blood associated with pressure volume 2 under development

4) Confidence 0.22 Published 1987 Journal Brain Res. Section Abstract Doc Link 2825914 Disease Relevance 0.10 Pain Relevance 0.15

General Comments

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