INT251834

Context Info Confidence 0.59 First Reported 2008 Last Reported 2009 Negated 0 Speculated 4 Reported most in Body Documents 5 Total Number 8 Disease Relevance 3.95 Pain Relevance 1.38

cell differentiation (ANG) DNA binding (ANG) extracellular space (ANG) extracellular region (ANG) cell death (ANG) nucleolus (ANG)

Anatomy Link Frequency endometrium 8 blood 2 peritoneal fluid 2 ANG (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory mediators 7 99.24 endometriosis 266 98.72 Inflammation 8 80.72 antagonist 2 5.88 bradykinin 11 5.00 Dismenorea 7 5.00 aspirin 1 5.00 fibrosis 1 5.00 Pain 1 5.00 agonist 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 15 99.04 Endometriosis 308 98.72 Pre-eclampsia 33 85.60 Reprotox - General 3 70 84.64 Cyst 7 69.08 Disease 16 54.64 Increased Venous Pressure Under Development 13 5.00 Myoma 7 5.00 Ovarian Cysts 7 5.00 Carcinoma In Situ 7 5.00

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Despite lack of data, it may also be speculated that an increased level of angiogenin in the circulating blood or peritoneal fluid promote the establishment of endometriotic lesions in the pelvic cavity, and once endometriotic lesions have been established and progressed to advanced stage, unknown adverse events, such as impairment of luteal steroidogenesis or release of local inflammatory mediators inhibiting response to progesterone, reduce the expression of angiogenin in the eutopic endometrium.

Negative_regulation (reduce) of Gene_expression (expression) of angiogenin in peritoneal fluid associated with endometriosis and inflammatory mediators

1) Confidence 0.59 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.78 Pain Relevance 0.24

It is possible that a relative deficiency of angiogenin expression in patients with advanced stage endometriosis leads to a defect in the angiogenic process that is essential for successful implantation.

Spec (possible) Negative_regulation (deficiency) of Gene_expression (expression) of angiogenin associated with endometriosis

2) Confidence 0.59 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.27 Pain Relevance 0.10

At present, however, it is unclear whether the relative deficiency of angiogenin expression in the secretory phase is inherent to the eutopic endometrium itself or the secondary consequence of other factors associated with ovarian endometrioma.

Spec (whether) Negative_regulation (deficiency) of Gene_expression (expression) of angiogenin in endometrium associated with endometriosis

3) Confidence 0.59 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.28 Pain Relevance 0.09

Although further studies are required to elucidate the relevance of angiogenin to the process of implantation, these findings suggest that the relative deficiency of angiogenin expression could be one of the critical factors involved in the mechanism by which endometriosis impairs fertility.

Negative_regulation (deficiency) of Gene_expression (expression) of angiogenin associated with endometriosis

4) Confidence 0.59 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.61 Pain Relevance 0.25

Despite these limits, we have found that the expression of angiogenin is decreased in the eutopic endometrium from women with advanced stage endometriosis during the normal window of implantation.

Negative_regulation (decreased) of Gene_expression (expression) of angiogenin in endometrium associated with endometriosis

5) Confidence 0.59 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.82 Pain Relevance 0.26

These findings suggest that the relative deficiency of angiogenin expression in the secretory endometrium could impair implantation in women with advanced stage endometriosis.

Negative_regulation (deficiency) of Gene_expression (expression) of angiogenin in endometrium associated with endometriosis

6) Confidence 0.43 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2579997 Disease Relevance 0.46 Pain Relevance 0.19

Based upon the specific enhancement of angiogenin expression around the implantation window period along with its strong angiogenic activity, it is necessary to investigate whether the expression of angiogenin in the eutopic endometrium is different between women with and without endometriosis.

Spec (whether) Negative_regulation (different) of Gene_expression (expression) of angiogenin in endometrium associated with endometriosis

7) Confidence 0.43 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.64 Pain Relevance 0.25

The low levels of Ang-(1–7) and ACE2 in the RUPP model may represent an inhibition of the vasodilator arm of the renin-angiotensin system associated with factors generated by the reduced placental blood flow (sFlt-1, TNF-?

Spec (may) Negative_regulation (represent) of Gene_expression (levels) of Ang in blood

8) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.09 Pain Relevance 0

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