INT251949

Context Info Confidence 0.43 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 7 Disease Relevance 4.16 Pain Relevance 0.30

Golgi apparatus (PRNP) endoplasmic reticulum (PRNP) nucleolus (PRNP) plasma membrane (PRNP) nucleus (PRNP) cell cycle (PRNP)

Anatomy Link Frequency brain 2 plaques 2 body 2 PRNP (Homo sapiens)

Pain Link Frequency Relevance Heat cerebral cortex 3 100.00 Spinal cord 15 74.96 Thalamus 6 70.40 iatrogenic 16 69.20 Hippocampus 8 66.76 Central nervous system 9 60.16 medulla 6 54.84 Nucleus accumbens 1 53.12 Inflammation 6 48.36 amygdala 1 42.92

Disease Link Frequency Relevance Heat Creutzfeldt Jakob Disease 147 100.00 Infection 45 98.76 Drug Induced Neurotoxicity 6 98.76 Disease 186 98.36 Lewy Body Disease 3 97.76 Kuru 49 97.36 Gliosis 9 96.60 Prion Diseases 18 93.76 Amyloid Plaque 10 90.36 Targeted Disruption 147 90.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The severity of neurotoxicity correlates with the level of Dpl expression [134] and can be rescued by PrPC expression [135], indicating that PrPC, Dpl and ?

Negative_regulation (rescued) of Gene_expression (expression) of PrPC associated with drug induced neurotoxicity

1) Confidence 0.43 Published 2010 Journal Neuropathology and Applied Neurobiology Section Body Doc Link PMC3017745 Disease Relevance 0.42 Pain Relevance 0.06

Abnormal PrP was present as synaptic deposits when present at low density and at higher density formed dense plaques, which varied in size, ranging from small dense granules to plaques of up to 30??

Negative_regulation (deposits) of Gene_expression (present) of PrP in plaques

2) Confidence 0.37 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2581659 Disease Relevance 0.71 Pain Relevance 0.19

In particular, we show that the aSCR amplitude, as estimated by DCM inversion, discloses CS+ and CS?

Negative_regulation (discloses) of Gene_expression (amplitude) of aSCR

3) Confidence 0.30 Published 2010 Journal Biological Psychology Section Body Doc Link PMC2923733 Disease Relevance 0 Pain Relevance 0

Indeed, the higher rate of de novo PrPSc formation reported in the study by Deleault and colleagues, who used only 48 PMCA cycles per round [4], indicates that using polyanions and purified PrPC may favor spontaneous prion formation, suggesting that some factors in brain homogenate may prevent PrP misfolding.

Negative_regulation (prevent) of Gene_expression (misfolding) of PrP in brain

4) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2675078 Disease Relevance 0.06 Pain Relevance 0

Furthermore, Rodriguez and colleagues [79] analyzed AQP1 and AQP4 expression in the cerebral cortex of CJD patients compared to that in cases with AD and diffuse Lewy body disease (DLB).

Spec (analyzed) Negative_regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of CJD in body associated with creutzfeldt jakob disease, lewy body disease, disease and cerebral cortex

5) Confidence 0.05 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.53 Pain Relevance 0.05

We also used PrP genotype and capture location in grouping deer, but did not use these covariates in our analyses; instead, we paired pairs of male and female deer by capture location and genotype and then used these groups of four individuals (n?

Negative_regulation (used) of Gene_expression (genotype) of PrP

6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2602978 Disease Relevance 0.52 Pain Relevance 0

There is a single report describing the expression of mouse prion protein (residues 23-231) in C. elegans [64].

Negative_regulation (describing) of Gene_expression (expression) of prion protein

7) Confidence 0.03 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2762972 Disease Relevance 0.91 Pain Relevance 0

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