INT252145

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Context Info
Confidence 0.3261196600
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in NULL
Documents 9
Total Number 9

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) transport (Napb) vesicle-mediated transport (Napb)
plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Mention Frequency
neurons 3
plasma 2
bands 1
Napb (Mus musculus)
Snap25 (Mus musculus)
Pain Relations:

(frequency)

Thalamus (4)

High High

Hippocampus (43)

Quite High

isoflurane (8)

Quite High

Glutamate (2)

Quite High

gABA (1)

Quite High

Catecholamines (17)

Low Low

depression of nerve function (8)

Very Low Very Low Very Low

Cholecystokinin (48)

Very Low Very Low Very Low

Disease Relations:

(frequency)

Dislocations (1)

Very Low Very Low Very Low

Tremor (16)

Very Low Very Low Very Low

Decapitation (9)

Very Low Very Low Very Low

Retina Disease (8)

Very Low Very Low Very Low

Alcohol Intoxication (8)

Very Low Very Low Very Low

Cognitive Disorder (56)

Very Low Very Low Very Low

Neurodegenerative Disease (16)

Very Low Very Low Very Low

Stress (8)

Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Event Anatomy Negation Speculation Pain term
Taken together with other studies [5,10,11], these results provide additional evidence that SNAP-25b is a key component of the neural SNARE complex responsible for both GABAergic and glutamatergic transmission in mature neurons.


SNARE Binding (complex) of SNAP-25b in neurons
1) Confidence 0.194688144144247 Published 2008 Journal N/A Section N/A Doc Link PMC2600647
The different stability of SNARE complexes found in neo-excised SNAP-25b deficient mutants compared to WT mice (Figure 2E) and that SNAP-25b demonstrates an increased association with plasma membrane fractions compared to SNAP-25a (see Text S1, Figure S2) suggest that SNAP-25a and SNAP-25b are differently associated with SNARE complexes close to, or immediately upstream of fusion.
SNARE Binding (associated) of SNAP-25a in plasma
2) Confidence 0.131431529950277 Published 2008 Journal N/A Section N/A Doc Link PMC2581893
The different stability of SNARE complexes found in neo-excised SNAP-25b deficient mutants compared to WT mice (Figure 2E) and that SNAP-25b demonstrates an increased association with plasma membrane fractions compared to SNAP-25a (see Text S1, Figure S2) suggest that SNAP-25a and SNAP-25b are differently associated with SNARE complexes close to, or immediately upstream of fusion.
SNARE Binding (associated) of SNAP-25b in plasma
3) Confidence 0.131431529950277 Published 2008 Journal N/A Section N/A Doc Link PMC2581893
To measure the grade of disassembly of heat-resistant SNARE complex in WT and SNAP-25b KO tissue, percentage monomeric SNAP-25 protein of total SNAP-25 in ternary complex at 4°C was calculated and compared with the value calculated at a certain temperature.
SNARE Binding (complex) of SNAP-25
4) Confidence 0.119227494325505 Published 2008 Journal N/A Section N/A Doc Link PMC2581893
To measure the grade of disassembly of heat-resistant SNARE complex in WT and SNAP-25b KO tissue, percentage monomeric SNAP-25 protein of total SNAP-25 in ternary complex at 4°C was calculated and compared with the value calculated at a certain temperature.
SNARE Binding (complex) of SNAP-25b
5) Confidence 0.119227494325505 Published 2008 Journal N/A Section N/A Doc Link PMC2581893
500,000) was used to detect immunoreactivity of bands migrating as ternary SNARE complex or solitaire SNAP-25 protein.
SNARE Binding (complex) of SNAP-25 protein in bands
6) Confidence 0.119227494325505 Published 2008 Journal N/A Section N/A Doc Link PMC2581893
In the SNARE complex with syntaxin and VAMP, SNAP-25 contributes with two amphipathic ?
SNARE Binding (complex) of SNAP-25
7) Confidence 0.114605754376932 Published 2008 Journal N/A Section N/A Doc Link PMC2581893
The SNAP-25b(Bdr) SNARE complexes, apparently more stable than complexes with WT SNAP-25b, result in impairment of both spontaneous and evoked release from cortical neurons and lack of facilitation during trains of high-frequency stimulation [48].
SNARE Binding (complexes) of SNAP-25b in neurons
8) Confidence 0.114605754376932 Published 2008 Journal N/A Section N/A Doc Link PMC2581893
The SNAP-25b(Bdr) SNARE complexes, apparently more stable than complexes with WT SNAP-25b, result in impairment of both spontaneous and evoked release from cortical neurons and lack of facilitation during trains of high-frequency stimulation [48].
SNARE Binding (complexes) of SNAP-25b in neurons
9) Confidence 0.114605754376932 Published 2008 Journal N/A Section N/A Doc Link PMC2581893

General Comments

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