INT252330

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.72 Pain Relevance 0.19

cell adhesion (Cd36, Cd47) plasma membrane (Cd36, Cd47) lipid binding (Cd36) transport (Cd36) mitochondrion (Cd36) Golgi apparatus (Cd36)

Anatomy Link Frequency blood 1 fibroblasts 1 Cd36 (Mus musculus) Cd47 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 43 97.44 cytokine 8 90.28 Kinase C 6 84.76 rheumatoid arthritis 14 62.96 psoriasis 1 42.68 chemokine 2 27.76 tolerance 6 14.56 abatacept 2 5.00 cva 2 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Synovitis 1 98.60 INFLAMMATION 43 97.44 Colitis 6 87.24 Carcinoma 5 85.84 Cleidocranial Dysplasia 3 85.24 Retinoblastoma 1 81.28 Stress 2 72.96 Rheumatoid Arthritis 14 62.96 Psoriasis 1 42.68 Disease 14 39.32

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Anatomy

Negation

Speculation

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More recently, TSP1 has been reported to block the pro-angiogenic effects of nitric oxide (NO) in endothelial and vascular smooth muscle cells.(33) Low level of NO are anti-inflammatory, but in inflamed tissues the levels of NO increase and blood flow, vascular permeability and angiogenesis are enhanced.(11) By interacting with their receptors CD36 and CD47, TSP1 prevents the pro-angiogenic effects of NO and makes EC more susceptible to its inhibition.(33)

CD36 Binding (interacting) of CD47 in blood associated with inflammation

1) Confidence 0.10 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.49 Pain Relevance 0.07

CD47 and thrombospondin can form a trimolecular complex with CD36 expressed on synovial fibroblasts.

CD36 Binding (complex) of CD47 in fibroblasts

2) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.23 Pain Relevance 0.12

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