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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.40
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Tnfrsf1a) extracellular region (TNF, Tnfrsf1a) signal transduction (TNF)
nucleus (Tnfrsf1a) plasma membrane (TNF) intracellular (TNF)
TNF (Homo sapiens)
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 90.52 High High
rheumatoid arthritis 16 89.20 High High
Inflammation 78 84.88 Quite High
cytokine 20 79.24 Quite High
Arthritis 19 72.76 Quite High
ischemia 28 69.52 Quite High
cva 3 57.16 Quite High
Infliximab 8 43.28 Quite Low
antagonist 4 36.64 Quite Low
Adalimumab 8 35.60 Quite Low
Disease Link Frequency Relevance Heat
Death 22 99.96 Very High Very High Very High
Disease 22 93.52 High High
Viral Infection 1 92.56 High High
Rheumatoid Arthritis 16 89.20 High High
INFLAMMATION 78 84.88 Quite High
Autoimmune Disease 2 83.76 Quite High
Stress 4 82.64 Quite High
Apoptosis 32 82.04 Quite High
Necrosis 7 77.28 Quite High
Cancer 8 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For TNF receptor 1 (TNFR1), it has been shown that binding of TNF-?
TNF Binding (binding) of TNFR1
1) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.48 Pain Relevance 0
Once released, soluble TNF circulates as a homotrimer that will bind with one of two distinct receptors of 55-kDa (TNFR1) or 75-kDa (TNFR2) molecular weight.
TNF Binding (bind) of TNFR1
2) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.57 Pain Relevance 0.16
is implicated in both cell proliferation and cell death; TNFR1 is generally associated with TNF?
TNF Binding (associated) of TNFR1 associated with death
3) Confidence 0.01 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2584631 Disease Relevance 0.40 Pain Relevance 0.03
Both sTNF and tmTNF ligands interact with either of 2 distinct receptors—TNF receptor 1 (TNFR1, p55, CD120a) and TNF receptor 2 (TNFR2, p75, CD120b)—on a wide variety of cell types to mediate their biological functions [2], [3].
tmTNF Binding (interact) of TNFR1
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 0.94 Pain Relevance 0.27

General Comments

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