INT252657

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.09
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
respiratory 4
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 80.60 Quite High
Inflammatory response 2 79.08 Quite High
cytokine 2 76.76 Quite High
corticosteroid 8 64.12 Quite High
melanocortin 1 receptor 158 62.20 Quite High
Bile 8 5.00 Very Low Very Low Very Low
drug abuse 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 12 100.00 Very High Very High Very High
Acute Renal Failure 4 100.00 Very High Very High Very High
Retinoblastoma 1 99.84 Very High Very High Very High
Necrosis 8 98.08 Very High Very High Very High
Disseminated Intravascular Coagulation 12 97.20 Very High Very High Very High
Communicable Diseases 2 89.20 High High
Cancer 13 89.08 High High
Melanoma 154 87.00 High High
INFLAMMATION 13 80.60 Quite High
Apoptosis 2 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This protein is known to inhibit the cyclin-dependent kinase 4 (CDK4mediated phosphorylation of retinoblastoma 1 protein and prevents the cell from progressing through the G1 cell cycle checkpoint (3,4).
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of CDK4 associated with retinoblastoma
1) Confidence 0.45 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.15 Pain Relevance 0.12
AF: alkaline phosphatase; ALAT: alanine aminotransferase; APTT: activated partial thromboplastin time; ARDS: adult respiratory distress syndrome; ARF: acute renal failure; ASAT: aspartate aminotransferase; C-RP: C-reactive protein; CT: computed tomography; DIC: disseminated intravascular coagulation; ?
Spec (partial) Positive_regulation (activated) of Phosphorylation (alkaline phosphatase) of ARF in respiratory associated with acute renal failure, disseminated intravascular coagulation and adult respiratory distress syndrome
2) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.97 Pain Relevance 0.15
AF: alkaline phosphatase; ALAT: alanine aminotransferase; APTT: activated partial thromboplastin time; ARDS: adult respiratory distress syndrome; ARF: acute renal failure; ASAT: aspartate aminotransferase; C-RP: C-reactive protein; CT: computed tomography; DIC: disseminated intravascular coagulation; ?
Positive_regulation (aspartate) of Phosphorylation (alkaline phosphatase) of ARF in respiratory associated with acute renal failure, disseminated intravascular coagulation and adult respiratory distress syndrome
3) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.97 Pain Relevance 0.15

General Comments

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