INT252723

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.67
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SYK) cytosol (SYK) plasma membrane (SYK)
cytoplasm (SYK)
Anatomy Link Frequency
B-cell 1
SYK (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 1 92.96 High High
chemokine 16 87.64 High High
cytokine 27 76.80 Quite High
Inflammation 51 74.72 Quite High
Kinase C 1 30.80 Quite Low
fibrosis 19 5.00 Very Low Very Low Very Low
alcohol 12 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sclerosis 11 92.00 High High
Hodgkin's Disease 269 91.76 High High
T-cell Lymphoma 42 91.52 High High
Cancer 112 90.16 High High
Eosinophilia 4 85.48 High High
Death 58 79.88 Quite High
Apoptosis 67 78.24 Quite High
INFLAMMATION 61 74.72 Quite High
Stress 107 72.60 Quite High
Lymphatic System Cancer 247 69.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recent finding of SYK/ITK translocations in rare PTCLs led us to examine the expression of Syk PTK in 141 PTCLs.
Spec (examine) Gene_expression (expression) of Syk
1) Confidence 0.25 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.69 Pain Relevance 0.04
Overexpression of Syk, phosphorylation of its Y525/526 residues, and the availability of orally available Syk inhibitors suggest that Syk merits further evaluation as a candidate target for pharmacologic PTK inhibition in patients with PTCL [16].
Gene_expression (Overexpression) of Syk
2) Confidence 0.25 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.67 Pain Relevance 0.03
by the kinase Syk (thus, independently of I?
Gene_expression (by) of kinase Syk
3) Confidence 0.22 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.42 Pain Relevance 0.15
Before this finding, though, the origin of HRS was highly speculative because the cells rarely express typical B-cell markers such as BCR, CD19, CD20, A-myb, and Syk—thus an HRS cell's immunophenotype is not reflective of its origin.
Gene_expression (express) of Syk in B-cell
4) Confidence 0.10 Published 2011 Journal Advances in Hematology Section Body Doc Link PMC2994062 Disease Relevance 0.90 Pain Relevance 0

General Comments

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